Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling

The transcriptional adaptation processes of harmful self-reactive CD8+ T cells in the central nervous system are not well understood. Here the authors use a system in which self-reactive and virally generated CD8+ T cells are directly compared in vivo and demonstrate that TOX expression contributes...

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Main Authors:	Nicolas Page, Sylvain Lemeille, Ilena Vincenti, Bogna Klimek, Alexandre Mariotte, Ingrid Wagner, Giovanni Di Liberto, Jonathan Kaye, Doron Merkler
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21109-3

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spelling	doaj-0a1022f34c2d437e8a387d622d23d03f2021-02-14T12:12:17ZengNature Publishing GroupNature Communications2041-17232021-02-0112111410.1038/s41467-021-21109-3Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodelingNicolas Page0Sylvain Lemeille1Ilena Vincenti2Bogna Klimek3Alexandre Mariotte4Ingrid Wagner5Giovanni Di Liberto6Jonathan Kaye7Doron Merkler8Department of Pathology and Immunology, University of GenevaDepartment of Pathology and Immunology, University of GenevaDepartment of Pathology and Immunology, University of GenevaDepartment of Pathology and Immunology, University of GenevaDepartment of Pathology and Immunology, University of GenevaDepartment of Pathology and Immunology, University of GenevaDepartment of Pathology and Immunology, University of GenevaResearch Division of Immunology, Departments of Biomedical Sciences and Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical CenterDepartment of Pathology and Immunology, University of GenevaThe transcriptional adaptation processes of harmful self-reactive CD8+ T cells in the central nervous system are not well understood. Here the authors use a system in which self-reactive and virally generated CD8+ T cells are directly compared in vivo and demonstrate that TOX expression contributes to maintenance of auto-reactive CD8+ T cells through alteration of chromatin accessibility.https://doi.org/10.1038/s41467-021-21109-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nicolas Page Sylvain Lemeille Ilena Vincenti Bogna Klimek Alexandre Mariotte Ingrid Wagner Giovanni Di Liberto Jonathan Kaye Doron Merkler
spellingShingle	Nicolas Page Sylvain Lemeille Ilena Vincenti Bogna Klimek Alexandre Mariotte Ingrid Wagner Giovanni Di Liberto Jonathan Kaye Doron Merkler Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling Nature Communications
author_facet	Nicolas Page Sylvain Lemeille Ilena Vincenti Bogna Klimek Alexandre Mariotte Ingrid Wagner Giovanni Di Liberto Jonathan Kaye Doron Merkler
author_sort	Nicolas Page
title	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_short	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_full	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_fullStr	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_full_unstemmed	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_sort	persistence of self-reactive cd8+ t cells in the cns requires tox-dependent chromatin remodeling
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-02-01
description	The transcriptional adaptation processes of harmful self-reactive CD8+ T cells in the central nervous system are not well understood. Here the authors use a system in which self-reactive and virally generated CD8+ T cells are directly compared in vivo and demonstrate that TOX expression contributes to maintenance of auto-reactive CD8+ T cells through alteration of chromatin accessibility.
url	https://doi.org/10.1038/s41467-021-21109-3
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Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling

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