Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat
Melatonin and nitric oxide (NO) are involved in orofacial signal processing in the trigeminal sensory system. The aim of the present study was to examine the distribution of melatonin 1a-receptor (MT1) and its colocalization with nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) in th...
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doaj-0a1807abf0534cfc8bb091e7c19e8ece2020-11-25T01:19:31ZengPeerJ Inc.PeerJ2167-83592019-05-017e687710.7717/peerj.6877Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of ratYifan He0Wenguo Fan1Yue Xu2Yong liang Liu3Hongwen He4Fang Huang5Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, ChinaGuanghua School of Stomatology, Sun Yat-sen University, Guangzhou, ChinaGuanghua School of Stomatology, Sun Yat-sen University, Guangzhou, ChinaGuanghua School of Stomatology, Sun Yat-sen University, Guangzhou, ChinaGuanghua School of Stomatology, Sun Yat-sen University, Guangzhou, ChinaGuanghua School of Stomatology, Sun Yat-sen University, Guangzhou, ChinaMelatonin and nitric oxide (NO) are involved in orofacial signal processing in the trigeminal sensory system. The aim of the present study was to examine the distribution of melatonin 1a-receptor (MT1) and its colocalization with nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) in the spinal trigeminal nucleus (STN), the trigeminal ganglion (TG), and the mesencephalic trigeminal nucleus (MTN) in the rat, using histochemistry and immunohistochemistry. Our results show that MT1-positive neurons are widely distributed in the TG and the subnucleus caudalis of the STN. Furthermore, we found that MT1 colocalizes with NADPH-d throughout the TG and MTN, most extensively in the TG. The distribution pattern of MT1 and its colocalization with NADPH-d indicate that melatonin might play an important role in the trigeminal sensory system, which could be responsible for the regulation of NO levels.https://peerj.com/articles/6877.pdfNADPH-diaphoraseMesencephalic trieminal nucleusMelatonin 1a-receptorTrigeminal ganglionSpinal trigeminal nucleus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yifan He Wenguo Fan Yue Xu Yong liang Liu Hongwen He Fang Huang |
spellingShingle |
Yifan He Wenguo Fan Yue Xu Yong liang Liu Hongwen He Fang Huang Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat PeerJ NADPH-diaphorase Mesencephalic trieminal nucleus Melatonin 1a-receptor Trigeminal ganglion Spinal trigeminal nucleus |
author_facet |
Yifan He Wenguo Fan Yue Xu Yong liang Liu Hongwen He Fang Huang |
author_sort |
Yifan He |
title |
Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat |
title_short |
Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat |
title_full |
Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat |
title_fullStr |
Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat |
title_full_unstemmed |
Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat |
title_sort |
distribution and colocalization of melatonin 1a-receptor and nadph-d in the trigeminal system of rat |
publisher |
PeerJ Inc. |
series |
PeerJ |
issn |
2167-8359 |
publishDate |
2019-05-01 |
description |
Melatonin and nitric oxide (NO) are involved in orofacial signal processing in the trigeminal sensory system. The aim of the present study was to examine the distribution of melatonin 1a-receptor (MT1) and its colocalization with nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) in the spinal trigeminal nucleus (STN), the trigeminal ganglion (TG), and the mesencephalic trigeminal nucleus (MTN) in the rat, using histochemistry and immunohistochemistry. Our results show that MT1-positive neurons are widely distributed in the TG and the subnucleus caudalis of the STN. Furthermore, we found that MT1 colocalizes with NADPH-d throughout the TG and MTN, most extensively in the TG. The distribution pattern of MT1 and its colocalization with NADPH-d indicate that melatonin might play an important role in the trigeminal sensory system, which could be responsible for the regulation of NO levels. |
topic |
NADPH-diaphorase Mesencephalic trieminal nucleus Melatonin 1a-receptor Trigeminal ganglion Spinal trigeminal nucleus |
url |
https://peerj.com/articles/6877.pdf |
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