Evaluation of Tumour Associated Tissue Eosinophilia and Other Histomorphological Variants as Markers of Metastasis in Squamous Cell Carcinomas
Introduction: Tumour Associated Tissue Eosinophilia (TATE), is characterised by the presence of eosinophils as a component of peri and intratumoral inflammatory response. Though lymphocytes are widely recognised in inducing favourable tumour microenvironment, the association with tissue eosinoph...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-12-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10942/30634_CE(Ra1)_F(SS)_PF1(PrG_RJ_OM)_PFA(MJ_GG)_PF2(AnG_PrG)_PFA2(PrG_MJ_AP).pdf |
| Summary: | Introduction: Tumour Associated Tissue Eosinophilia (TATE), is
characterised by the presence of eosinophils as a component
of peri and intratumoral inflammatory response. Though
lymphocytes are widely recognised in inducing favourable tumour
microenvironment, the association with tissue eosinophilia has
been infrequently studied.
Aim: This study was undertaken to assess the grades of Tumour
Associated Tissue Eosinophilia (TATE) and its association
with various neoplastic histopathological variables, host
tissue inflammatory reaction and the presence or absence of
metastases.
Materials and Methods: Surgically resected or biopsy
specimens (n=148) from patients with squamous cell
carcinomas, who had not received any chemotherapy and/ or
radiotherapy were included. Those with coexisting tumours, or
demonstrating large areas of ulceration and/or necrosis were
excluded. TATE was graded from 0 to 4+ depending upon
the number of eosinophils/High Power Field (HPF). Tumour
morphology, metastases and a variety of other histopathological
variables were also observed.
Results: High grades of TATE (3+ and 4+) were found in 60.8%
of well differentiated squamous cell carcinomas, and were
associated with pushing borders (82.3%), intense inflammatory
infiltrate (62.7%) and high grade desmoplasia (92.1%). In
contrast, low grades of TATE were associated with infiltrating
borders (76.2%), low grades of desmoplasia (51.5%) cases and
moderate inflammatory infiltrate (59.7%). Tumour metastasized
in 45.9% cases of which 89.7% were seen to be associated
with low grades of TATE. The association between low grades
of TATE and metastases as determined by Chi-square test was
highly significant (p<0.001).
Conclusion: High grades of TATE are associated with lesser
tendency of tumour metastasis and hence may be considered a
favourable prognostic marker in squamous cell carcinomas. |
|---|---|
| ISSN: | 2249-782X 0973-709X |