Changes in Functional Glucocorticoid Sensitivity of Isolated Splenocytes Induced by Chronic Psychosocial Stress – A Time Course Study

Changes in Functional Glucocorticoid Sensitivity of Isolated Splenocytes Induced by Chronic Psychosocial Stress – A Time Course Study

Chronic psychosocial stress is a risk factor for the development of numerous disorders, of which most are associated with chronic low-grade inflammation. Given the immunosuppressive effects of glucocorticoids (GC), one underlying mechanism might be the development of stress-induced GC resistance in...

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Bibliographic Details
Main Authors: Elena Kempter, Mattia Amoroso, Hannah L. Duffner, Andrea M. Werner, Dominik Langgartner, Sandra Kupfer, Stefan O. Reber
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
chronic psychosocial stress
chronic subordinate colony housing (CSC)
glucocorticoid resistance
corticosterone
spleen
bite wounds
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.753822/full

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