Altered DNA methylation patterns of the H19 differentially methylated region and the DAZL gene promoter are associated with defective human sperm.

Altered DNA methylation patterns of the H19 differentially methylated region and the DAZL gene promoter are associated with defective human sperm.

DNA methylation disturbance is associated with defective human sperm. However, oligozoospermia (OZ) and asthenozoospermia (AZ) usually present together, and the relationship between the single-phenotype defects in human sperm and DNA methylation is poorly understood. In this study, 20 infertile OZ p...

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Bibliographic Details
Main Authors: Bo Li, Jian-bo Li, Xi-feng Xiao, Ye-fei Ma, Jun Wang, Xin-xin Liang, Hong-xi Zhao, Feng Jiang, Yuan-qing Yao, Xiao-hong Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3756053?pdf=render

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