Development of rat metabolic syndrome models: A review
Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the mo...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Veterinary World
2021-07-01
|
Series: | Veterinary World |
Subjects: | |
Online Access: | http://www.veterinaryworld.org/Vol.14/July-2021/7.pdf |
id |
doaj-0a439c69d64045869e1a32dd5c6e742d |
---|---|
record_format |
Article |
spelling |
doaj-0a439c69d64045869e1a32dd5c6e742d2021-07-07T12:53:17ZengVeterinary WorldVeterinary World0972-89882231-09162021-07-011471774178310.14202/vetworld.2021.1774-1783Development of rat metabolic syndrome models: A reviewShirly Gunawan0https://orcid.org/0000-0001-9197-772XAhmad Aulia1https://orcid.org/0000-0002-7266-5832Vivian Soetikno2https://orcid.org/0000-0002-2123-6448Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia; Doctoral Programme in Biomedical Science Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study.http://www.veterinaryworld.org/Vol.14/July-2021/7.pdfhigh-fat diethigh-fructose diethigh-sucrose dietmetabolic syndromerat models |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shirly Gunawan Ahmad Aulia Vivian Soetikno |
spellingShingle |
Shirly Gunawan Ahmad Aulia Vivian Soetikno Development of rat metabolic syndrome models: A review Veterinary World high-fat diet high-fructose diet high-sucrose diet metabolic syndrome rat models |
author_facet |
Shirly Gunawan Ahmad Aulia Vivian Soetikno |
author_sort |
Shirly Gunawan |
title |
Development of rat metabolic syndrome models: A review |
title_short |
Development of rat metabolic syndrome models: A review |
title_full |
Development of rat metabolic syndrome models: A review |
title_fullStr |
Development of rat metabolic syndrome models: A review |
title_full_unstemmed |
Development of rat metabolic syndrome models: A review |
title_sort |
development of rat metabolic syndrome models: a review |
publisher |
Veterinary World |
series |
Veterinary World |
issn |
0972-8988 2231-0916 |
publishDate |
2021-07-01 |
description |
Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. |
topic |
high-fat diet high-fructose diet high-sucrose diet metabolic syndrome rat models |
url |
http://www.veterinaryworld.org/Vol.14/July-2021/7.pdf |
work_keys_str_mv |
AT shirlygunawan developmentofratmetabolicsyndromemodelsareview AT ahmadaulia developmentofratmetabolicsyndromemodelsareview AT viviansoetikno developmentofratmetabolicsyndromemodelsareview |
_version_ |
1721315609666387968 |