Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle
The Epstein–Barr virus (EBV) is a ubiquitous virus that infects most of the human population. EBV infection is associated with multiple human cancers, including Burkitt’s lymphoma, Hodgkin’s lymphoma, a subset of gastric carcinomas, and almost all undifferentiated non-keratinizing nasopharyngeal car...
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Online Access: | https://www.mdpi.com/1999-4915/9/11/341 |
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doaj-0a496371f07f4860a7e68cacbd6388c22020-11-25T00:07:27ZengMDPI AGViruses1999-49152017-11-0191134110.3390/v9110341v9110341Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life CyclePok Man Hau0Sai Wah Tsao1Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaThe Epstein–Barr virus (EBV) is a ubiquitous virus that infects most of the human population. EBV infection is associated with multiple human cancers, including Burkitt’s lymphoma, Hodgkin’s lymphoma, a subset of gastric carcinomas, and almost all undifferentiated non-keratinizing nasopharyngeal carcinoma. Intensive research has shown that EBV triggers a DNA damage response (DDR) during primary infection and lytic reactivation. The EBV-encoded viral proteins have been implicated in deregulating the DDR signaling pathways. The consequences of DDR inactivation lead to genomic instability and promote cellular transformation. This review summarizes the current understanding of the relationship between EBV infection and the DDR transducers, including ATM (ataxia telangiectasia mutated), ATR (ATM and Rad3-related), and DNA-PK (DNA-dependent protein kinase), and discusses how EBV manipulates the DDR signaling pathways to complete the replication process of viral DNA during lytic reactivation.https://www.mdpi.com/1999-4915/9/11/341Epstein–Barr virusDNA damage responselytic reactivation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pok Man Hau Sai Wah Tsao |
spellingShingle |
Pok Man Hau Sai Wah Tsao Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle Viruses Epstein–Barr virus DNA damage response lytic reactivation |
author_facet |
Pok Man Hau Sai Wah Tsao |
author_sort |
Pok Man Hau |
title |
Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle |
title_short |
Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle |
title_full |
Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle |
title_fullStr |
Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle |
title_full_unstemmed |
Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle |
title_sort |
epstein–barr virus hijacks dna damage response transducers to orchestrate its life cycle |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2017-11-01 |
description |
The Epstein–Barr virus (EBV) is a ubiquitous virus that infects most of the human population. EBV infection is associated with multiple human cancers, including Burkitt’s lymphoma, Hodgkin’s lymphoma, a subset of gastric carcinomas, and almost all undifferentiated non-keratinizing nasopharyngeal carcinoma. Intensive research has shown that EBV triggers a DNA damage response (DDR) during primary infection and lytic reactivation. The EBV-encoded viral proteins have been implicated in deregulating the DDR signaling pathways. The consequences of DDR inactivation lead to genomic instability and promote cellular transformation. This review summarizes the current understanding of the relationship between EBV infection and the DDR transducers, including ATM (ataxia telangiectasia mutated), ATR (ATM and Rad3-related), and DNA-PK (DNA-dependent protein kinase), and discusses how EBV manipulates the DDR signaling pathways to complete the replication process of viral DNA during lytic reactivation. |
topic |
Epstein–Barr virus DNA damage response lytic reactivation |
url |
https://www.mdpi.com/1999-4915/9/11/341 |
work_keys_str_mv |
AT pokmanhau epsteinbarrvirushijacksdnadamageresponsetransducerstoorchestrateitslifecycle AT saiwahtsao epsteinbarrvirushijacksdnadamageresponsetransducerstoorchestrateitslifecycle |
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1725418072126259200 |