Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial Infarction
Objective: Growth differentiation factor-8 (GDF8), also known as myostatin, is a member of the transforming growth factor-β superfamily that inhibits skeletal muscle growth. We aimed to investigate the association between GDF8 and peak troponin I levels after acute myocardial infarction (AM...
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doaj-0a4b07b0c7a14f9288470d77a85735532020-11-25T01:29:43ZengMDPI AGJournal of Clinical Medicine2077-03832019-12-019111610.3390/jcm9010116jcm9010116Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial InfarctionAlexandre Meloux0Luc Rochette1Maud Maza2Florence Bichat3Laura Tribouillard4Yves Cottin5Marianne Zeller6Catherine Vergely7Laboratoire Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA 7460), Université de Bourgogne-Franche-Comté, UFR des Sciences de Santé; 7 Bd Jeanne d’Arc, 21000 Dijon, FranceLaboratoire Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA 7460), Université de Bourgogne-Franche-Comté, UFR des Sciences de Santé; 7 Bd Jeanne d’Arc, 21000 Dijon, FranceLaboratoire Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA 7460), Université de Bourgogne-Franche-Comté, UFR des Sciences de Santé; 7 Bd Jeanne d’Arc, 21000 Dijon, FranceLaboratoire Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA 7460), Université de Bourgogne-Franche-Comté, UFR des Sciences de Santé; 7 Bd Jeanne d’Arc, 21000 Dijon, FranceDepartment of Cardiology, University Hospital of Dijon, 21000 Dijon, FranceLaboratoire Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA 7460), Université de Bourgogne-Franche-Comté, UFR des Sciences de Santé; 7 Bd Jeanne d’Arc, 21000 Dijon, FranceLaboratoire Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA 7460), Université de Bourgogne-Franche-Comté, UFR des Sciences de Santé; 7 Bd Jeanne d’Arc, 21000 Dijon, FranceLaboratoire Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA 7460), Université de Bourgogne-Franche-Comté, UFR des Sciences de Santé; 7 Bd Jeanne d’Arc, 21000 Dijon, FranceObjective: Growth differentiation factor-8 (GDF8), also known as myostatin, is a member of the transforming growth factor-β superfamily that inhibits skeletal muscle growth. We aimed to investigate the association between GDF8 and peak troponin I levels after acute myocardial infarction (AMI). Methods: All consecutive patients admitted from June 2016 to February 2018 for type 1 AMI in the Coronary Care Unit of University Hospital of Dijon Bourgogne (France) were included in our prospective study. Blood samples were harvested on admission, and serum levels of GDF8 were measured using a commercially available enzyme-linked immunosorbent assay kit. Results: Among the 296 patients with type 1 AMI, median age was 68 years and 27% were women. GDF8 levels (median (IQR) = 2375 ng/L) were negatively correlated with age, sex and diabetes (<i>p</i> < 0.001 for all). GDF8 levels were higher in patients with in-hospital ventricular tachycardia or fibrillation (VT/VF) than those without in-hospital VT/VF. GDF8 was positively correlated with troponin I peak (r = 0.247; <i>p</i> < 0.001). In multivariate linear regression analysis, log GDF8 (OR: 21.59; 95% CI 34.08−119.05; <i>p</i> < 0.001) was an independent predictor of troponin I peak. Conclusions: These results suggest that GDF8 levels could reflect the extent of myocardial damage during AMI, similar to peak troponin I, which is currently used to estimate infarct size. Further studies are needed to elucidate the underlying mechanisms linking the GDF8 cytokine with troponin I levels.https://www.mdpi.com/2077-0383/9/1/116gdf8myostatinamitroponin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexandre Meloux Luc Rochette Maud Maza Florence Bichat Laura Tribouillard Yves Cottin Marianne Zeller Catherine Vergely |
spellingShingle |
Alexandre Meloux Luc Rochette Maud Maza Florence Bichat Laura Tribouillard Yves Cottin Marianne Zeller Catherine Vergely Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial Infarction Journal of Clinical Medicine gdf8 myostatin ami troponin |
author_facet |
Alexandre Meloux Luc Rochette Maud Maza Florence Bichat Laura Tribouillard Yves Cottin Marianne Zeller Catherine Vergely |
author_sort |
Alexandre Meloux |
title |
Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial Infarction |
title_short |
Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial Infarction |
title_full |
Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial Infarction |
title_fullStr |
Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial Infarction |
title_full_unstemmed |
Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial Infarction |
title_sort |
growth differentiation factor-8 (gdf8)/myostatin is a predictor of troponin i peak and a marker of clinical severity after acute myocardial infarction |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-12-01 |
description |
Objective: Growth differentiation factor-8 (GDF8), also known as myostatin, is a member of the transforming growth factor-β superfamily that inhibits skeletal muscle growth. We aimed to investigate the association between GDF8 and peak troponin I levels after acute myocardial infarction (AMI). Methods: All consecutive patients admitted from June 2016 to February 2018 for type 1 AMI in the Coronary Care Unit of University Hospital of Dijon Bourgogne (France) were included in our prospective study. Blood samples were harvested on admission, and serum levels of GDF8 were measured using a commercially available enzyme-linked immunosorbent assay kit. Results: Among the 296 patients with type 1 AMI, median age was 68 years and 27% were women. GDF8 levels (median (IQR) = 2375 ng/L) were negatively correlated with age, sex and diabetes (<i>p</i> < 0.001 for all). GDF8 levels were higher in patients with in-hospital ventricular tachycardia or fibrillation (VT/VF) than those without in-hospital VT/VF. GDF8 was positively correlated with troponin I peak (r = 0.247; <i>p</i> < 0.001). In multivariate linear regression analysis, log GDF8 (OR: 21.59; 95% CI 34.08−119.05; <i>p</i> < 0.001) was an independent predictor of troponin I peak. Conclusions: These results suggest that GDF8 levels could reflect the extent of myocardial damage during AMI, similar to peak troponin I, which is currently used to estimate infarct size. Further studies are needed to elucidate the underlying mechanisms linking the GDF8 cytokine with troponin I levels. |
topic |
gdf8 myostatin ami troponin |
url |
https://www.mdpi.com/2077-0383/9/1/116 |
work_keys_str_mv |
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