The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension
Background: We previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. A number of adipocyte-derived factors are implicated in BP control in obesity.Aim: The aim of this study was...
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Frontiers Media S.A.
2017-05-01
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Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00369/full |
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English |
format |
Article |
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author |
Nina Eikelis Nina Eikelis Dagmara Hering Dagmara Hering Petra Marusic Petra Marusic Jacqueline Duval Louise J. Hammond Antony S. Walton Elisabeth A. Lambert Elisabeth A. Lambert Murray D. Esler Murray D. Esler Gavin W. Lambert Gavin W. Lambert Markus P. Schlaich Markus P. Schlaich Markus P. Schlaich |
spellingShingle |
Nina Eikelis Nina Eikelis Dagmara Hering Dagmara Hering Petra Marusic Petra Marusic Jacqueline Duval Louise J. Hammond Antony S. Walton Elisabeth A. Lambert Elisabeth A. Lambert Murray D. Esler Murray D. Esler Gavin W. Lambert Gavin W. Lambert Markus P. Schlaich Markus P. Schlaich Markus P. Schlaich The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension Frontiers in Physiology renal denervation resistant hypertension obesity non-esterified fatty acids adiponectin |
author_facet |
Nina Eikelis Nina Eikelis Dagmara Hering Dagmara Hering Petra Marusic Petra Marusic Jacqueline Duval Louise J. Hammond Antony S. Walton Elisabeth A. Lambert Elisabeth A. Lambert Murray D. Esler Murray D. Esler Gavin W. Lambert Gavin W. Lambert Markus P. Schlaich Markus P. Schlaich Markus P. Schlaich |
author_sort |
Nina Eikelis |
title |
The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension |
title_short |
The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension |
title_full |
The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension |
title_fullStr |
The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension |
title_full_unstemmed |
The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension |
title_sort |
effect of renal denervation on plasma adipokine profile in patients with treatment resistant hypertension |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2017-05-01 |
description |
Background: We previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. A number of adipocyte-derived factors are implicated in BP control in obesity.Aim: The aim of this study was to examine whether RDN may have salutary effects on the adipokine profile in patients with resistant hypertension (RH).Methods: Fifty seven patients with RH undergoing RDN program have been included in this study (65% males, age 60.8 ± 1.5 years, BMI 32.6 ± 0.7 kg/m2, mean ± SEM). Throughout the study, the patients were on an average of 4.5 ± 2.7 antihypertensive drugs. Automated seated office BP measurements and plasma concentrations of leptin, insulin, non-esterified fatty acids (NEFA), adiponectin and resistin were assessed at baseline and the 3 months after RDN.Results: There was a significant reduction in mean office systolic (168.75 ± 2.57 vs. 155.23 ± 3.17 mmHg, p < 0.001) and diastolic (90.68 ± 2.31 vs. 83.74 ± 2.36 mmHg, p < 0.001) BP 3 months after RDN. Body weight, plasma leptin and resistin levels and heart rate remained unchanged. Fasting insulin concentration significantly increased 3 months after the procedure (20.05 ± 1.46 vs. 29.70 ± 2.51 uU/ml, p = 0.002). There was a significant drop in circulating NEFA at follow up (1.01 ± 0.07 vs. 0.47 ± 0.04 mEq/l, p < 0.001). Adiponectin concentration was significantly higher after RDN (5,654 ± 800 vs. 6,644 ± 967 ng/ml, p = 0.024).Conclusions: This is the first study to demonstrate that RDN is associated with potentially beneficial effects on aspects of the adipokine profile. Increased adiponectin and reduced NEFA production may contribute to BP reduction via an effect on metabolic pathways.Clinical Trial Registration Number: NCT00483808, NCT00888433. |
topic |
renal denervation resistant hypertension obesity non-esterified fatty acids adiponectin |
url |
http://journal.frontiersin.org/article/10.3389/fphys.2017.00369/full |
work_keys_str_mv |
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doaj-0a5621e445614bfa99a08d7fbb5ec8542020-11-24T22:01:37ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-05-01810.3389/fphys.2017.00369259482The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant HypertensionNina Eikelis0Nina Eikelis1Dagmara Hering2Dagmara Hering3Petra Marusic4Petra Marusic5Jacqueline Duval6Louise J. Hammond7Antony S. Walton8Elisabeth A. Lambert9Elisabeth A. Lambert10Murray D. Esler11Murray D. Esler12Gavin W. Lambert13Gavin W. Lambert14Markus P. Schlaich15Markus P. Schlaich16Markus P. Schlaich17Human Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaIverson Health Innovation Research Institute, Swinburne University of TechnologyMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaSchool of Medicine and Pharmacology - Royal Perth Hospital Unit, University of Western AustraliaPerth, WA, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaSchool of Medicine and Pharmacology - Royal Perth Hospital Unit, University of Western AustraliaPerth, WA, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaHeart Centre Alfred HospitalMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaIverson Health Innovation Research Institute, Swinburne University of TechnologyMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaHeart Centre Alfred HospitalMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaIverson Health Innovation Research Institute, Swinburne University of TechnologyMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaSchool of Medicine and Pharmacology - Royal Perth Hospital Unit, University of Western AustraliaPerth, WA, AustraliaHeart Centre Alfred HospitalMelbourne, VIC, AustraliaBackground: We previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. A number of adipocyte-derived factors are implicated in BP control in obesity.Aim: The aim of this study was to examine whether RDN may have salutary effects on the adipokine profile in patients with resistant hypertension (RH).Methods: Fifty seven patients with RH undergoing RDN program have been included in this study (65% males, age 60.8 ± 1.5 years, BMI 32.6 ± 0.7 kg/m2, mean ± SEM). Throughout the study, the patients were on an average of 4.5 ± 2.7 antihypertensive drugs. Automated seated office BP measurements and plasma concentrations of leptin, insulin, non-esterified fatty acids (NEFA), adiponectin and resistin were assessed at baseline and the 3 months after RDN.Results: There was a significant reduction in mean office systolic (168.75 ± 2.57 vs. 155.23 ± 3.17 mmHg, p < 0.001) and diastolic (90.68 ± 2.31 vs. 83.74 ± 2.36 mmHg, p < 0.001) BP 3 months after RDN. Body weight, plasma leptin and resistin levels and heart rate remained unchanged. Fasting insulin concentration significantly increased 3 months after the procedure (20.05 ± 1.46 vs. 29.70 ± 2.51 uU/ml, p = 0.002). There was a significant drop in circulating NEFA at follow up (1.01 ± 0.07 vs. 0.47 ± 0.04 mEq/l, p < 0.001). Adiponectin concentration was significantly higher after RDN (5,654 ± 800 vs. 6,644 ± 967 ng/ml, p = 0.024).Conclusions: This is the first study to demonstrate that RDN is associated with potentially beneficial effects on aspects of the adipokine profile. Increased adiponectin and reduced NEFA production may contribute to BP reduction via an effect on metabolic pathways.Clinical Trial Registration Number: NCT00483808, NCT00888433.http://journal.frontiersin.org/article/10.3389/fphys.2017.00369/fullrenal denervationresistant hypertensionobesitynon-esterified fatty acidsadiponectin |