The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension

Background: We previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. A number of adipocyte-derived factors are implicated in BP control in obesity.Aim: The aim of this study was...

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Main Authors: Nina Eikelis, Dagmara Hering, Petra Marusic, Jacqueline Duval, Louise J. Hammond, Antony S. Walton, Elisabeth A. Lambert, Murray D. Esler, Gavin W. Lambert, Markus P. Schlaich
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00369/full
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language English
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author Nina Eikelis
Nina Eikelis
Dagmara Hering
Dagmara Hering
Petra Marusic
Petra Marusic
Jacqueline Duval
Louise J. Hammond
Antony S. Walton
Elisabeth A. Lambert
Elisabeth A. Lambert
Murray D. Esler
Murray D. Esler
Gavin W. Lambert
Gavin W. Lambert
Markus P. Schlaich
Markus P. Schlaich
Markus P. Schlaich
spellingShingle Nina Eikelis
Nina Eikelis
Dagmara Hering
Dagmara Hering
Petra Marusic
Petra Marusic
Jacqueline Duval
Louise J. Hammond
Antony S. Walton
Elisabeth A. Lambert
Elisabeth A. Lambert
Murray D. Esler
Murray D. Esler
Gavin W. Lambert
Gavin W. Lambert
Markus P. Schlaich
Markus P. Schlaich
Markus P. Schlaich
The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension
Frontiers in Physiology
renal denervation
resistant hypertension
obesity
non-esterified fatty acids
adiponectin
author_facet Nina Eikelis
Nina Eikelis
Dagmara Hering
Dagmara Hering
Petra Marusic
Petra Marusic
Jacqueline Duval
Louise J. Hammond
Antony S. Walton
Elisabeth A. Lambert
Elisabeth A. Lambert
Murray D. Esler
Murray D. Esler
Gavin W. Lambert
Gavin W. Lambert
Markus P. Schlaich
Markus P. Schlaich
Markus P. Schlaich
author_sort Nina Eikelis
title The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension
title_short The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension
title_full The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension
title_fullStr The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension
title_full_unstemmed The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension
title_sort effect of renal denervation on plasma adipokine profile in patients with treatment resistant hypertension
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2017-05-01
description Background: We previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. A number of adipocyte-derived factors are implicated in BP control in obesity.Aim: The aim of this study was to examine whether RDN may have salutary effects on the adipokine profile in patients with resistant hypertension (RH).Methods: Fifty seven patients with RH undergoing RDN program have been included in this study (65% males, age 60.8 ± 1.5 years, BMI 32.6 ± 0.7 kg/m2, mean ± SEM). Throughout the study, the patients were on an average of 4.5 ± 2.7 antihypertensive drugs. Automated seated office BP measurements and plasma concentrations of leptin, insulin, non-esterified fatty acids (NEFA), adiponectin and resistin were assessed at baseline and the 3 months after RDN.Results: There was a significant reduction in mean office systolic (168.75 ± 2.57 vs. 155.23 ± 3.17 mmHg, p < 0.001) and diastolic (90.68 ± 2.31 vs. 83.74 ± 2.36 mmHg, p < 0.001) BP 3 months after RDN. Body weight, plasma leptin and resistin levels and heart rate remained unchanged. Fasting insulin concentration significantly increased 3 months after the procedure (20.05 ± 1.46 vs. 29.70 ± 2.51 uU/ml, p = 0.002). There was a significant drop in circulating NEFA at follow up (1.01 ± 0.07 vs. 0.47 ± 0.04 mEq/l, p < 0.001). Adiponectin concentration was significantly higher after RDN (5,654 ± 800 vs. 6,644 ± 967 ng/ml, p = 0.024).Conclusions: This is the first study to demonstrate that RDN is associated with potentially beneficial effects on aspects of the adipokine profile. Increased adiponectin and reduced NEFA production may contribute to BP reduction via an effect on metabolic pathways.Clinical Trial Registration Number: NCT00483808, NCT00888433.
topic renal denervation
resistant hypertension
obesity
non-esterified fatty acids
adiponectin
url http://journal.frontiersin.org/article/10.3389/fphys.2017.00369/full
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spelling doaj-0a5621e445614bfa99a08d7fbb5ec8542020-11-24T22:01:37ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-05-01810.3389/fphys.2017.00369259482The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant HypertensionNina Eikelis0Nina Eikelis1Dagmara Hering2Dagmara Hering3Petra Marusic4Petra Marusic5Jacqueline Duval6Louise J. Hammond7Antony S. Walton8Elisabeth A. Lambert9Elisabeth A. Lambert10Murray D. Esler11Murray D. Esler12Gavin W. Lambert13Gavin W. Lambert14Markus P. Schlaich15Markus P. Schlaich16Markus P. Schlaich17Human Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaIverson Health Innovation Research Institute, Swinburne University of TechnologyMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaSchool of Medicine and Pharmacology - Royal Perth Hospital Unit, University of Western AustraliaPerth, WA, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaSchool of Medicine and Pharmacology - Royal Perth Hospital Unit, University of Western AustraliaPerth, WA, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaHeart Centre Alfred HospitalMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaIverson Health Innovation Research Institute, Swinburne University of TechnologyMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaHeart Centre Alfred HospitalMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaIverson Health Innovation Research Institute, Swinburne University of TechnologyMelbourne, VIC, AustraliaHuman Neurotransmitters and Neurovascular Hypertension and Kidney Disease Laboratories, Baker Heart and Diabetes InstituteMelbourne, VIC, AustraliaSchool of Medicine and Pharmacology - Royal Perth Hospital Unit, University of Western AustraliaPerth, WA, AustraliaHeart Centre Alfred HospitalMelbourne, VIC, AustraliaBackground: We previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. A number of adipocyte-derived factors are implicated in BP control in obesity.Aim: The aim of this study was to examine whether RDN may have salutary effects on the adipokine profile in patients with resistant hypertension (RH).Methods: Fifty seven patients with RH undergoing RDN program have been included in this study (65% males, age 60.8 ± 1.5 years, BMI 32.6 ± 0.7 kg/m2, mean ± SEM). Throughout the study, the patients were on an average of 4.5 ± 2.7 antihypertensive drugs. Automated seated office BP measurements and plasma concentrations of leptin, insulin, non-esterified fatty acids (NEFA), adiponectin and resistin were assessed at baseline and the 3 months after RDN.Results: There was a significant reduction in mean office systolic (168.75 ± 2.57 vs. 155.23 ± 3.17 mmHg, p < 0.001) and diastolic (90.68 ± 2.31 vs. 83.74 ± 2.36 mmHg, p < 0.001) BP 3 months after RDN. Body weight, plasma leptin and resistin levels and heart rate remained unchanged. Fasting insulin concentration significantly increased 3 months after the procedure (20.05 ± 1.46 vs. 29.70 ± 2.51 uU/ml, p = 0.002). There was a significant drop in circulating NEFA at follow up (1.01 ± 0.07 vs. 0.47 ± 0.04 mEq/l, p < 0.001). Adiponectin concentration was significantly higher after RDN (5,654 ± 800 vs. 6,644 ± 967 ng/ml, p = 0.024).Conclusions: This is the first study to demonstrate that RDN is associated with potentially beneficial effects on aspects of the adipokine profile. Increased adiponectin and reduced NEFA production may contribute to BP reduction via an effect on metabolic pathways.Clinical Trial Registration Number: NCT00483808, NCT00888433.http://journal.frontiersin.org/article/10.3389/fphys.2017.00369/fullrenal denervationresistant hypertensionobesitynon-esterified fatty acidsadiponectin