Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China
Background . A newborn screening program (NSP) for congenital hypothyroidism (CH) was carried out in Guangxi in order to understand the incidence of CH and the factors interrelated to major types of CH in this region of China. Methods . During 2009 to 2013, data from 930 612 newborns attending NSP i...
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doaj-0a5a0f5da1994549bd71ea18209728d62020-11-25T03:34:22ZengSAGE PublishingGlobal Pediatric Health2333-794X2015-01-01210.1177/2333794X1456719310.1177_2333794X14567193Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, ChinaXin Fan MD0Shaoke Chen MD1Jiale Qian MD2Suren Sooranna PhD3Jingi Luo MD4Chuan Li MD5Qin Tang MD6Caijuan Lin MD7Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaMaternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaMaternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaChelsea and Westminster Hospital, London, UKMaternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaMaternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaMaternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaMaternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaBackground . A newborn screening program (NSP) for congenital hypothyroidism (CH) was carried out in Guangxi in order to understand the incidence of CH and the factors interrelated to major types of CH in this region of China. Methods . During 2009 to 2013, data from 930 612 newborns attending NSP in Guangxi were collected. Patients were classified with either permanent CH (PCH) or transient CH (TCH) after 2 years of progressive study. Results . A total of 1210 patients were confirmed with CH with an incidence of 1/769, including 68 PCH and 126 TCH cases with incidences of 1/6673 and 1/3385, respectively. The frequency of thyroid stimulating hormone values greater than 5 mIU/L was 7.2%, which, based on WHO guidelines, suggests that the population was mildly iodine deficient. Conclusions . The incidence of CH was high in Guangxi. Approximately two thirds of CH patients were TCH, which may be due to a deficiency in iodine within the population.https://doi.org/10.1177/2333794X14567193 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xin Fan MD Shaoke Chen MD Jiale Qian MD Suren Sooranna PhD Jingi Luo MD Chuan Li MD Qin Tang MD Caijuan Lin MD |
spellingShingle |
Xin Fan MD Shaoke Chen MD Jiale Qian MD Suren Sooranna PhD Jingi Luo MD Chuan Li MD Qin Tang MD Caijuan Lin MD Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China Global Pediatric Health |
author_facet |
Xin Fan MD Shaoke Chen MD Jiale Qian MD Suren Sooranna PhD Jingi Luo MD Chuan Li MD Qin Tang MD Caijuan Lin MD |
author_sort |
Xin Fan MD |
title |
Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China |
title_short |
Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China |
title_full |
Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China |
title_fullStr |
Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China |
title_full_unstemmed |
Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China |
title_sort |
incidence and interrelated factors in patients with congenital hypothyroidism as detected by newborn screening in guangxi, china |
publisher |
SAGE Publishing |
series |
Global Pediatric Health |
issn |
2333-794X |
publishDate |
2015-01-01 |
description |
Background . A newborn screening program (NSP) for congenital hypothyroidism (CH) was carried out in Guangxi in order to understand the incidence of CH and the factors interrelated to major types of CH in this region of China. Methods . During 2009 to 2013, data from 930 612 newborns attending NSP in Guangxi were collected. Patients were classified with either permanent CH (PCH) or transient CH (TCH) after 2 years of progressive study. Results . A total of 1210 patients were confirmed with CH with an incidence of 1/769, including 68 PCH and 126 TCH cases with incidences of 1/6673 and 1/3385, respectively. The frequency of thyroid stimulating hormone values greater than 5 mIU/L was 7.2%, which, based on WHO guidelines, suggests that the population was mildly iodine deficient. Conclusions . The incidence of CH was high in Guangxi. Approximately two thirds of CH patients were TCH, which may be due to a deficiency in iodine within the population. |
url |
https://doi.org/10.1177/2333794X14567193 |
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