An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes

Eukaryotic cells may divide via the critical cellular process of cell division/mitosis, resulting in two daughter cells with the same genetic information. A large number of dedicated proteins are involved in this process and spatiotemporally assembled into three distinct super-complex structures/org...

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Main Authors: Yueyuan eZheng, Junjie eGuo, Xu eLi, Yubin eXie, Mingming eHou, Xuyang eFu, Shengkun eDai, Rucheng eDiao, Yanyan eMiao, Jian eRen
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Microbiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00573/full
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spelling doaj-0a5af06eba0c4506978b8359fe21a0722020-11-24T23:26:30ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2014-10-01510.3389/fmicb.2014.00573117802An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexesYueyuan eZheng0Junjie eGuo1Xu eLi2Yubin eXie3Mingming eHou4Xuyang eFu5Shengkun eDai6Rucheng eDiao7Yanyan eMiao8Jian eRen9Sun Yat-sen UniversitySun Yat-sen UniversityOrthopaedic Department of Anhui Medical University Affiliated Provincial HospitalSun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversityEukaryotic cells may divide via the critical cellular process of cell division/mitosis, resulting in two daughter cells with the same genetic information. A large number of dedicated proteins are involved in this process and spatiotemporally assembled into three distinct super-complex structures/organelles, including the centrosome/spindle pole body, kinetochore/centromere and cleavage furrow/midbody/bud neck, so as to precisely modulate the cell division/mitosis events of chromosome alignment, chromosome segregation and cytokinesis in an orderly fashion. In recent years, many efforts have been made to identify the protein components and architecture of these subcellular organelles, aiming to uncover the organelle assembly pathways, determine the molecular mechanisms underlying the organelle functions, and thereby provide new therapeutic strategies for a variety of diseases. However, the organelles are highly dynamic structures, making it difficult to identify the entire components. Here, we review the current knowledge of the identified protein components governing the organization and functioning of organelles, especially in human and yeast cells, and discuss the multi-localized protein components mediating the communication between organelles during cell division.http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00573/fullCentrosomekinetochoreSuper-complex structurescell division/mitosisprotein componentsmidbody
collection DOAJ
language English
format Article
sources DOAJ
author Yueyuan eZheng
Junjie eGuo
Xu eLi
Yubin eXie
Mingming eHou
Xuyang eFu
Shengkun eDai
Rucheng eDiao
Yanyan eMiao
Jian eRen
spellingShingle Yueyuan eZheng
Junjie eGuo
Xu eLi
Yubin eXie
Mingming eHou
Xuyang eFu
Shengkun eDai
Rucheng eDiao
Yanyan eMiao
Jian eRen
An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes
Frontiers in Microbiology
Centrosome
kinetochore
Super-complex structures
cell division/mitosis
protein components
midbody
author_facet Yueyuan eZheng
Junjie eGuo
Xu eLi
Yubin eXie
Mingming eHou
Xuyang eFu
Shengkun eDai
Rucheng eDiao
Yanyan eMiao
Jian eRen
author_sort Yueyuan eZheng
title An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes
title_short An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes
title_full An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes
title_fullStr An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes
title_full_unstemmed An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes
title_sort integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes
publisher Frontiers Media S.A.
series Frontiers in Microbiology
issn 1664-302X
publishDate 2014-10-01
description Eukaryotic cells may divide via the critical cellular process of cell division/mitosis, resulting in two daughter cells with the same genetic information. A large number of dedicated proteins are involved in this process and spatiotemporally assembled into three distinct super-complex structures/organelles, including the centrosome/spindle pole body, kinetochore/centromere and cleavage furrow/midbody/bud neck, so as to precisely modulate the cell division/mitosis events of chromosome alignment, chromosome segregation and cytokinesis in an orderly fashion. In recent years, many efforts have been made to identify the protein components and architecture of these subcellular organelles, aiming to uncover the organelle assembly pathways, determine the molecular mechanisms underlying the organelle functions, and thereby provide new therapeutic strategies for a variety of diseases. However, the organelles are highly dynamic structures, making it difficult to identify the entire components. Here, we review the current knowledge of the identified protein components governing the organization and functioning of organelles, especially in human and yeast cells, and discuss the multi-localized protein components mediating the communication between organelles during cell division.
topic Centrosome
kinetochore
Super-complex structures
cell division/mitosis
protein components
midbody
url http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00573/full
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