An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes
Eukaryotic cells may divide via the critical cellular process of cell division/mitosis, resulting in two daughter cells with the same genetic information. A large number of dedicated proteins are involved in this process and spatiotemporally assembled into three distinct super-complex structures/org...
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doaj-0a5af06eba0c4506978b8359fe21a0722020-11-24T23:26:30ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2014-10-01510.3389/fmicb.2014.00573117802An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexesYueyuan eZheng0Junjie eGuo1Xu eLi2Yubin eXie3Mingming eHou4Xuyang eFu5Shengkun eDai6Rucheng eDiao7Yanyan eMiao8Jian eRen9Sun Yat-sen UniversitySun Yat-sen UniversityOrthopaedic Department of Anhui Medical University Affiliated Provincial HospitalSun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversityEukaryotic cells may divide via the critical cellular process of cell division/mitosis, resulting in two daughter cells with the same genetic information. A large number of dedicated proteins are involved in this process and spatiotemporally assembled into three distinct super-complex structures/organelles, including the centrosome/spindle pole body, kinetochore/centromere and cleavage furrow/midbody/bud neck, so as to precisely modulate the cell division/mitosis events of chromosome alignment, chromosome segregation and cytokinesis in an orderly fashion. In recent years, many efforts have been made to identify the protein components and architecture of these subcellular organelles, aiming to uncover the organelle assembly pathways, determine the molecular mechanisms underlying the organelle functions, and thereby provide new therapeutic strategies for a variety of diseases. However, the organelles are highly dynamic structures, making it difficult to identify the entire components. Here, we review the current knowledge of the identified protein components governing the organization and functioning of organelles, especially in human and yeast cells, and discuss the multi-localized protein components mediating the communication between organelles during cell division.http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00573/fullCentrosomekinetochoreSuper-complex structurescell division/mitosisprotein componentsmidbody |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yueyuan eZheng Junjie eGuo Xu eLi Yubin eXie Mingming eHou Xuyang eFu Shengkun eDai Rucheng eDiao Yanyan eMiao Jian eRen |
spellingShingle |
Yueyuan eZheng Junjie eGuo Xu eLi Yubin eXie Mingming eHou Xuyang eFu Shengkun eDai Rucheng eDiao Yanyan eMiao Jian eRen An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes Frontiers in Microbiology Centrosome kinetochore Super-complex structures cell division/mitosis protein components midbody |
author_facet |
Yueyuan eZheng Junjie eGuo Xu eLi Yubin eXie Mingming eHou Xuyang eFu Shengkun eDai Rucheng eDiao Yanyan eMiao Jian eRen |
author_sort |
Yueyuan eZheng |
title |
An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes |
title_short |
An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes |
title_full |
An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes |
title_fullStr |
An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes |
title_full_unstemmed |
An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes |
title_sort |
integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2014-10-01 |
description |
Eukaryotic cells may divide via the critical cellular process of cell division/mitosis, resulting in two daughter cells with the same genetic information. A large number of dedicated proteins are involved in this process and spatiotemporally assembled into three distinct super-complex structures/organelles, including the centrosome/spindle pole body, kinetochore/centromere and cleavage furrow/midbody/bud neck, so as to precisely modulate the cell division/mitosis events of chromosome alignment, chromosome segregation and cytokinesis in an orderly fashion. In recent years, many efforts have been made to identify the protein components and architecture of these subcellular organelles, aiming to uncover the organelle assembly pathways, determine the molecular mechanisms underlying the organelle functions, and thereby provide new therapeutic strategies for a variety of diseases. However, the organelles are highly dynamic structures, making it difficult to identify the entire components. Here, we review the current knowledge of the identified protein components governing the organization and functioning of organelles, especially in human and yeast cells, and discuss the multi-localized protein components mediating the communication between organelles during cell division. |
topic |
Centrosome kinetochore Super-complex structures cell division/mitosis protein components midbody |
url |
http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00573/full |
work_keys_str_mv |
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