Quality assessment of unsaturated iron-binding protein capacity in Iraqi patients undergoing hemodialysis
Hemodialysis is autoimmune disease result from inflammation, oxidative stress, and fibrosis. It is characterized by renal glomeruli damage, podocyte injury, tubule interstitial, and proteinuria. Electrolyte balance is the main function of the renal and any form of electrolyte disorders may lead to e...
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Wolters Kluwer Medknow Publications
2020-01-01
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doaj-0a7e0010c0bb4ddd87bbf6354c9664de2020-11-25T03:13:21ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062020-01-0112324625110.4103/jpbs.JPBS_12_20Quality assessment of unsaturated iron-binding protein capacity in Iraqi patients undergoing hemodialysisIsraa Burhan RaoofMayssaa E AbdalahHemodialysis is autoimmune disease result from inflammation, oxidative stress, and fibrosis. It is characterized by renal glomeruli damage, podocyte injury, tubule interstitial, and proteinuria. Electrolyte balance is the main function of the renal and any form of electrolyte disorders may lead to excess blood volume, hypertension, and difficulty in maintaining natural blood sodium. Renal erythropoietin has an important role in the balance of vascular active substances, such as prostaglandins and thromboxanes; therefore, patients undergoing hemodialysis observe decreased production of erythropoietin with iron loss through hemodialysis machine as well as weakened iron absorption and mobilization from the intestine to the bloodstream. Ferritin, total iron-binding capacity (TIBC), unsaturated iron-binding protein capacity (UIBC), iron free, and transferrin are used to confirm iron status. According the clinical characterization of the results, no normality was observed in patients undergoing hemodialysis. There was hypertension, anemia, lean symptoms and equal distribution of age parallel with developed disease, there was significant increased in renal function except albumin, it was decreased in the patients compared with control groups. In addition, there was a decreased level of iron status in all parameters such as packed cell volume (%), TIBC, UIBC, iron free, and transferrin except ferritin; there was an increased level of iron status in all parameters in patients compared with control groups.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=3;spage=246;epage=251;aulast=Raoofferritinhemodialysistotal iron-binding capacitytransferrinunsaturated iron-binding protein capacity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Israa Burhan Raoof Mayssaa E Abdalah |
spellingShingle |
Israa Burhan Raoof Mayssaa E Abdalah Quality assessment of unsaturated iron-binding protein capacity in Iraqi patients undergoing hemodialysis Journal of Pharmacy and Bioallied Sciences ferritin hemodialysis total iron-binding capacity transferrin unsaturated iron-binding protein capacity |
author_facet |
Israa Burhan Raoof Mayssaa E Abdalah |
author_sort |
Israa Burhan Raoof |
title |
Quality assessment of unsaturated iron-binding protein capacity in Iraqi patients undergoing hemodialysis |
title_short |
Quality assessment of unsaturated iron-binding protein capacity in Iraqi patients undergoing hemodialysis |
title_full |
Quality assessment of unsaturated iron-binding protein capacity in Iraqi patients undergoing hemodialysis |
title_fullStr |
Quality assessment of unsaturated iron-binding protein capacity in Iraqi patients undergoing hemodialysis |
title_full_unstemmed |
Quality assessment of unsaturated iron-binding protein capacity in Iraqi patients undergoing hemodialysis |
title_sort |
quality assessment of unsaturated iron-binding protein capacity in iraqi patients undergoing hemodialysis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Pharmacy and Bioallied Sciences |
issn |
0975-7406 |
publishDate |
2020-01-01 |
description |
Hemodialysis is autoimmune disease result from inflammation, oxidative stress, and fibrosis. It is characterized by renal glomeruli damage, podocyte injury, tubule interstitial, and proteinuria. Electrolyte balance is the main function of the renal and any form of electrolyte disorders may lead to excess blood volume, hypertension, and difficulty in maintaining natural blood sodium. Renal erythropoietin has an important role in the balance of vascular active substances, such as prostaglandins and thromboxanes; therefore, patients undergoing hemodialysis observe decreased production of erythropoietin with iron loss through hemodialysis machine as well as weakened iron absorption and mobilization from the intestine to the bloodstream. Ferritin, total iron-binding capacity (TIBC), unsaturated iron-binding protein capacity (UIBC), iron free, and transferrin are used to confirm iron status. According the clinical characterization of the results, no normality was observed in patients undergoing hemodialysis. There was hypertension, anemia, lean symptoms and equal distribution of age parallel with developed disease, there was significant increased in renal function except albumin, it was decreased in the patients compared with control groups. In addition, there was a decreased level of iron status in all parameters such as packed cell volume (%), TIBC, UIBC, iron free, and transferrin except ferritin; there was an increased level of iron status in all parameters in patients compared with control groups. |
topic |
ferritin hemodialysis total iron-binding capacity transferrin unsaturated iron-binding protein capacity |
url |
http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=3;spage=246;epage=251;aulast=Raoof |
work_keys_str_mv |
AT israaburhanraoof qualityassessmentofunsaturatedironbindingproteincapacityiniraqipatientsundergoinghemodialysis AT mayssaaeabdalah qualityassessmentofunsaturatedironbindingproteincapacityiniraqipatientsundergoinghemodialysis |
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