Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia

Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia

We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug co...

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Bibliographic Details
Main Authors: Jean Popovici, Amelie Vantaux, Lyse Primault, Reingsey Samreth, Eak Por Piv, Sophalai Bin, Saorin Kim, Dysoley Lek, David Serre, Didier Menard
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2018-08-01
Series:Emerging Infectious Diseases
Subjects:
malaria
Plasmodium vivax
parasites
chloroquine
CQ
dihydroartemisinin/piperaquine
Online Access:https://wwwnc.cdc.gov/eid/article/24/8/17-0768_article
id doaj-0a805ab101b249bd9f2a908113acc015
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spelling doaj-0a805ab101b249bd9f2a908113acc0152020-11-25T01:04:25ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-08-012481516151910.3201/eid2408.170768Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, CambodiaJean PopoviciAmelie VantauxLyse PrimaultReingsey SamrethEak Por PivSophalai BinSaorin KimDysoley LekDavid SerreDidier MenardWe assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >2 months.https://wwwnc.cdc.gov/eid/article/24/8/17-0768_articlemalariaPlasmodium vivaxparasiteschloroquineCQdihydroartemisinin/piperaquine
collection DOAJ
language English
format Article
sources DOAJ
author Jean Popovici
Amelie Vantaux
Lyse Primault
Reingsey Samreth
Eak Por Piv
Sophalai Bin
Saorin Kim
Dysoley Lek
David Serre
Didier Menard
spellingShingle Jean Popovici
Amelie Vantaux
Lyse Primault
Reingsey Samreth
Eak Por Piv
Sophalai Bin
Saorin Kim
Dysoley Lek
David Serre
Didier Menard
Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia
Emerging Infectious Diseases
malaria
Plasmodium vivax
parasites
chloroquine
CQ
dihydroartemisinin/piperaquine
author_facet Jean Popovici
Amelie Vantaux
Lyse Primault
Reingsey Samreth
Eak Por Piv
Sophalai Bin
Saorin Kim
Dysoley Lek
David Serre
Didier Menard
author_sort Jean Popovici
title Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia
title_short Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia
title_full Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia
title_fullStr Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia
title_full_unstemmed Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia
title_sort therapeutic and transmission-blocking 
efficacy of dihydroartemisinin/piperaquine and chloroquine against plasmodium vivax malaria, cambodia
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2018-08-01
description We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >2 months.
topic malaria
Plasmodium vivax
parasites
chloroquine
CQ
dihydroartemisinin/piperaquine
url https://wwwnc.cdc.gov/eid/article/24/8/17-0768_article
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