Emerging roles of hypoxia-inducible factors and reactive oxygen species in cancer and pluripotent stem cells

Eukaryotic organisms require oxygen homeostasis to maintain proper cellular function for survival. During conditions of low oxygen tension (hypoxia), cells activate the transcription of genes that induce an adaptive response, which supplies oxygen to tissues. Hypoxia and hypoxia-inducible factors (H...

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Bibliographic Details
Main Authors: Shigeo Saito, Ying-Chu Lin, Ming-Ho Tsai, Chang-Shen Lin, Yoshinobu Murayama, Ryuji Sato, Kazunari K. Yokoyama
Format: Article
Published: Wiley 2015-06-01
Series:Kaohsiung Journal of Medical Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1607551X1500090X