Computational Identification of the Paralogs and Orthologs of Human Cytochrome P450 Superfamily and the Implication in Drug Discovery

Computational Identification of the Paralogs and Orthologs of Human Cytochrome P450 Superfamily and the Implication in Drug Discovery

The human cytochrome P450 (CYP) superfamily consisting of 57 functional genes is the most important group of Phase I drug metabolizing enzymes that oxidize a large number of xenobiotics and endogenous compounds, including therapeutic drugs and environmental toxicants. The CYP superfamily has been sh...

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Bibliographic Details
Main Authors: Shu-Ting Pan, Danfeng Xue, Zhi-Ling Li, Zhi-Wei Zhou, Zhi-Xu He, Yinxue Yang, Tianxin Yang, Jia-Xuan Qiu, Shu-Feng Zhou
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
human CYP
drug metabolism
paralog
homolog
ortholog
comparative genomics
bioinformatics
Online Access:http://www.mdpi.com/1422-0067/17/7/1020

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