A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors

Biological polymeric matrices often use molecular anchors, such as antibodies, to trap nanoparticulates. Here, the authors find that anchor-matrix bonds that are weak and short-lived confer superior trapping potency, contrary to the prevailing belief that effective molecular anchors should form stro...

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Main Authors:	Jay Newby, Jennifer L. Schiller, Timothy Wessler, Jasmine Edelstein, M. Gregory Forest, Samuel K. Lai
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00739-6

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spelling	doaj-0a8f61c054d7499c8cfd1b1294055ed12021-05-11T07:57:09ZengNature Publishing GroupNature Communications2041-17232017-10-018111010.1038/s41467-017-00739-6A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchorsJay Newby0Jennifer L. Schiller1Timothy Wessler2Jasmine Edelstein3M. Gregory Forest4Samuel K. Lai5Department of Mathematics, University of North Carolina—Chapel HillDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina—Chapel HillDepartment of Mathematics, University of North Carolina—Chapel HillUNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina—Chapel HillDepartment of Mathematics, University of North Carolina—Chapel HillDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina—Chapel HillBiological polymeric matrices often use molecular anchors, such as antibodies, to trap nanoparticulates. Here, the authors find that anchor-matrix bonds that are weak and short-lived confer superior trapping potency, contrary to the prevailing belief that effective molecular anchors should form strong bonds to both the matrix and the nanoparticulates.https://doi.org/10.1038/s41467-017-00739-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jay Newby Jennifer L. Schiller Timothy Wessler Jasmine Edelstein M. Gregory Forest Samuel K. Lai
spellingShingle	Jay Newby Jennifer L. Schiller Timothy Wessler Jasmine Edelstein M. Gregory Forest Samuel K. Lai A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors Nature Communications
author_facet	Jay Newby Jennifer L. Schiller Timothy Wessler Jasmine Edelstein M. Gregory Forest Samuel K. Lai
author_sort	Jay Newby
title	A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_short	A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_full	A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_fullStr	A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_full_unstemmed	A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_sort	blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	Biological polymeric matrices often use molecular anchors, such as antibodies, to trap nanoparticulates. Here, the authors find that anchor-matrix bonds that are weak and short-lived confer superior trapping potency, contrary to the prevailing belief that effective molecular anchors should form strong bonds to both the matrix and the nanoparticulates.
url	https://doi.org/10.1038/s41467-017-00739-6
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A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors

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