Mutational profile of KIT and PDGFRA genes in gastrointestinal stromal tumors in Peruvian samples

Introduction: Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms usually caused by somatic mutations in the genes KIT (c-KIT) or PDGFRA. Mutation characterization has become an important exam for GIST patients because it is useful in predicting the response to the inhibitors of recept...

Full description

Bibliographic Details
Main Authors:	José Buleje, Óscar Acosta, María Guevara-Fujita, Yanina Enriquez, Luis Taxa, Enrique Machicado, Frank Lizaraso-Caparó, Ricardo Fujita
Format:	Article
Language:	English
Published:	Aran Ediciones 2015-02-01
Series:	Revista Espanola de Enfermedades Digestivas
Subjects:	KIT PDGFRA Gastrointestinal stromal tumors Mutational analysis
Online Access:	http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015000200003&lng=en&tlng=en

Similar Items

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour
by: Valli PRIYA, et al.
Published: (2020-05-01)

Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor
by: Sebastian Bauer, et al.
Published: (2021-07-01)

Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth
by: Eva Serrano‐Candelas, et al.
Published: (2018-08-01)

Integrated Molecular Characterization of Gastrointestinal Stromal Tumors (GIST) Harboring the Rare D842V Mutation in PDGFRA Gene
by: Valentina Indio, et al.
Published: (2018-03-01)

Prognostic factors in patients with disseminated gastrointestinal stromal tumors
by: P P Arkhiri, et al.
Published: (2016-06-01)

The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor
by: Annalisa Astolfi, et al.
Published: (2020-05-01)

Malignant melanoma of the conjunctiva: a case report with examination of KIT and PDGFRA
by: Tadashi Terada
Published: (2012-01-01)

Clinicopathologic characteristics, diagnostic clues, and prognoses of patients with multiple sporadic gastrointestinal stromal tumors: a case series and review of the literature
by: Yan-Ying Shen, et al.
Published: (2020-05-01)

Results on prognostic value of mutations in localized gastrointestinal stromal tumors (GIST): in one single center Valor pronóstico de las mutaciones en tumores estromales gastrointestinales localizados (GIST): resultados de un solo centro
by: Marina Garcés-Albir, et al.
Published: (2012-08-01)

The Identity of PDGFRA D842V-Mutant Gastrointestinal Stromal Tumors (GIST)
by: Alessandro Rizzo, et al.
Published: (2021-02-01)

Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors
by: César Serrano, et al.
Published: (2020-02-01)

Small cell carcinoma of the urinary bladder: KIT and PDGFRA gene mutations
by: Nuket Eliyakin, et al.
Published: (2015-12-01)

ALK expressed in a gastrointestinal stromal tumor harboring PDGFRA p. D842V mutation:a case report
by: Jun Fan, et al.
Published: (2020-01-01)

The importance of molecular biology in development, prognosis, treatment and resistance to targeted therapy in gastrointestinal stromal tumors
by: Alessandro Comandone, et al.
Published: (2011-12-01)

Molecular features and genetic markers of gastrointestinal stromal tumors
by: N. N. Mazurenko, et al.
Published: (2015-06-01)

Malignant melanoma of the nasal cavity: a case report with examination of KIT and platelet derived growth factor receptor-α (PDGFRA)
by: Tadashi Terada
Published: (2011-10-01)

Study of gastrointestinal stromal tumors with c-kit immunostaining
by: B Sigdel, et al.
Published: (2011-03-01)

Prediction of KIT Mutation in Gastrointestinal Stromal Tumors by the Immunoprofile of the Tumor Cells
by: Chu-Chung Chou, et al.
Published: (2010-01-01)

A case of KIT negative extra-gastrointestinal stromal tumor arising in the greater omentum with predominant cystic formation
by: Katsuya Nanjo, MD, et al.
Published: (2021-08-01)

Gastrointestinal stromal tumors (GISTs): role of CD 117 and PDGFRA Golgi-like staining pattern in the recognition of mutational status Tumores del estroma gastrointestinal (GISTs): patrón de tinción tipo Golgi de CD 117 Y PDGFRA en el reconocimiento del estado mutacional
by: Sara Jaramillo, et al.
Published: (2012-03-01)

Avapritinib: a new tyrosine kinase inhibitor for treatment of advanced gastrointestinal stromal tumors. The literature review and clinical case
by: Daria A. Filonenko, et al.
Published: (2021-02-01)

Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST
by: Annalisa Astolfi, et al.
Published: (2020-04-01)

Gastrointestinal Stromal Tumors of Small Intestine
by: Tanweerul Huda, et al.
Published: (2019-07-01)

A Case of KIT-Negative Extra-Gastrointestinal Stromal Tumor of the Lesser Omentum
by: Hisataka Ogawa, et al.
Published: (2012-06-01)

Advances and Challenges on Management of Gastrointestinal Stromal Tumors
by: Lin Mei, et al.
Published: (2018-05-01)

Frequency of KIT Mutation in Gastrointestinal Stromal Tumors According to Histologic and Immunohistochemical Findings, the First Report from Iran
by: Bita Geramizadeh, et al.
Published: (2015-07-01)

Update on Molecular Genetics of Gastrointestinal Stromal Tumors
by: Iva Brčić, et al.
Published: (2021-01-01)

Gastrointestinal stromal tumor of rectum- a case report
by: Madhuri S.Kate
Published: (2012-01-01)

Exon 11 homozygous mutations and intron 10/exon 11 junction deletions in the KIT gene are associated with poor prognosis of patients with gastrointestinal stromal tumors
by: Yan‐Ying Shen, et al.
Published: (2020-09-01)

Unraveling the spectrum of KIT mutations in gastrointestinal stromal tumors: An Indian Tertiary Cancer Center Experience
by: Trupti Pai, et al.
Published: (2017-01-01)

Gastrointestinal Stromal Tumours: A Review on Genetics, Pathology, Risk Stratification, Clinical Characteristics, Investigation, and Treatment
by: Md Tanveer Adil, et al.
Published: (2016-11-01)

Discovery of novel potential KIT inhibitors for the treatment of gastrointestinal stromal tumor
by: Jiang Lili, et al.
Published: (2021-04-01)

KIT exon 11 and PDGFRA exon 18 gene mutations in gastric GIST: proposal of a short panel for predicting therapeutic response
by: Denise Barcelos, et al.
Published: (2018-11-01)

Synchronous GISTs associated with multiple sporadic tumors: a case report
by: Danila Comandini, et al.
Published: (2017-08-01)

Gastrointestinal stromal tumor of rectum- a case report
by: Madhuri S.Kate, et al.
Published: (2012-11-01)

Large Gastrointestinal Stromal Tumor Mimicking A Gynecologic Tumor
by: Sew-Khee Yeat, et al.
Published: (2005-06-01)

Type and Gene Location of <i>KIT</i> Mutations Predict Progression-Free Survival to First-Line Imatinib in Gastrointestinal Stromal Tumors: A Look into the Exon
by: Lorena Incorvaia, et al.
Published: (2021-02-01)

Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors
by: Xuechao Liu, et al.
Published: (2019-10-01)

Gastrointestinal Stromal Tumors with Unusual Localization: Report of Three Cases with a Brief Literature Review
by: Ahmet Fikret Yucel, et al.
Published: (2010-07-01)

MORPHOLOGICAL AND IMMUNOCYTOCHEMICAL CHARACTERISTICS OF STROMAL GASTROINTESTINAL TUMORS
by: Ivan Ilić, et al.
Published: (2010-09-01)