Development of Classification Models for Identifying “True” P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays

Development of Classification Models for Identifying “True” P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays

P-glycoprotein (P-gp) is an efflux pump involved in the protection of tissues of several organs by influencing xenobiotic disposition. P-gp plays a key role in multidrug resistance and in the progression of many neurodegenerative diseases. The development of new and more effective therapeutics targe...

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Bibliographic Details
Main Authors: Anna Maria Bianucci, Simona Rapposelli, Alessio Coi, Marcello Imbriani
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:International Journal of Molecular Sciences
Subjects:
P-glicoprotein
decision trees
classification model
consensus model
P-gp inhibitors
MDR1 ligands
Online Access:http://www.mdpi.com/1422-0067/13/6/6924

Internet

http://www.mdpi.com/1422-0067/13/6/6924

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