Histomorphometric changes in the synovial membrane of the knee joint in combined use of the Ilizarov non-free bone plasty and the Masquelet technique (experimental study)
Relevance Defects of long bones result in anatomical and functional complex of pathologies in the entire limb. There are few fundamental studies of tissues adjacent to bone defects by using different technologies for management of long bone defects. Purpose To study the structural changes in the sy...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics
2021-04-01
|
Series: | Гений oртопедии |
Subjects: |
id |
doaj-0ac196ae502e448b9656d85b60c24380 |
---|---|
record_format |
Article |
spelling |
doaj-0ac196ae502e448b9656d85b60c243802021-04-21T04:14:42ZengRussian Ilizarov Scientific Center for Restorative Traumatology and OrthopaedicsГений oртопедии1028-44272542-131X2021-04-0127224925310.18019/1028-4427-2021-27-2-249-253Histomorphometric changes in the synovial membrane of the knee joint in combined use of the Ilizarov non-free bone plasty and the Masquelet technique (experimental study)Tatyana A. Stupina0Olga V. Diuriagina1Denis S. Mokhovikov2Yulia A. Stupina3Dmitry Yu. Borzunov4Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationIlizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationIlizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationTyumen State Medical University, Tyumen, Russian FederationUral State Medical University, Ekaterinburg, Russian Federation, Central City Clinical Hospital № 23, Ekaterinburg, Russian FederationRelevance Defects of long bones result in anatomical and functional complex of pathologies in the entire limb. There are few fundamental studies of tissues adjacent to bone defects by using different technologies for management of long bone defects. Purpose To study the structural changes in the synovial membrane of the knee joint by modelling the conditions for tibial defect management using the Ilizarov method of non-free bone plasty in combination with the Masquelet technique. Materials and methods The conditions of post-resection defect of the tibia (from 15 % of the segment length) by lengthening the distal fragment were modeled in ten mongrel dogs. Temporarily, for 30 days, a cement spacer was implanted into the post-resection defect gap. Upon its removal, the intermediate fragment in the lower third of the leg was transported at a rate of 1 mm in 4 steps until complete contact of the bone fragments. Histomorphometric studies of the synovium were carried out at the observation stages at the end of the fixation period (60 days) and after removing the apparatus (30 days). Results Two types of changes were revealed in the synovium: changes of a destructive nature without synovitis (30 % of cases) and with signs of synovitis (70 % of cases, 3 dogs had mild synovitis and 4 dogs had severe synovitis). Changes in the microvessels of the synovial membrane in synovitis indicated impaired microcirculation, high activity of angiogenesis and the development of hypervascularization. Conclusion Experimental management of the tibial bone defect by Ilizarov method in combination with the Masquelet technique revealed signs of synovitis of the knee joint in 70 % of cases using histophorphometry methods.synoviummorphometrylower leg defectnon-free bone plastyilizarov methodmasquelet technique |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tatyana A. Stupina Olga V. Diuriagina Denis S. Mokhovikov Yulia A. Stupina Dmitry Yu. Borzunov |
spellingShingle |
Tatyana A. Stupina Olga V. Diuriagina Denis S. Mokhovikov Yulia A. Stupina Dmitry Yu. Borzunov Histomorphometric changes in the synovial membrane of the knee joint in combined use of the Ilizarov non-free bone plasty and the Masquelet technique (experimental study) Гений oртопедии synovium morphometry lower leg defect non-free bone plasty ilizarov method masquelet technique |
author_facet |
Tatyana A. Stupina Olga V. Diuriagina Denis S. Mokhovikov Yulia A. Stupina Dmitry Yu. Borzunov |
author_sort |
Tatyana A. Stupina |
title |
Histomorphometric changes in the synovial membrane of the knee joint in combined use of the Ilizarov non-free bone plasty and the Masquelet technique (experimental study) |
title_short |
Histomorphometric changes in the synovial membrane of the knee joint in combined use of the Ilizarov non-free bone plasty and the Masquelet technique (experimental study) |
title_full |
Histomorphometric changes in the synovial membrane of the knee joint in combined use of the Ilizarov non-free bone plasty and the Masquelet technique (experimental study) |
title_fullStr |
Histomorphometric changes in the synovial membrane of the knee joint in combined use of the Ilizarov non-free bone plasty and the Masquelet technique (experimental study) |
title_full_unstemmed |
Histomorphometric changes in the synovial membrane of the knee joint in combined use of the Ilizarov non-free bone plasty and the Masquelet technique (experimental study) |
title_sort |
histomorphometric changes in the synovial membrane of the knee joint in combined use of the ilizarov non-free bone plasty and the masquelet technique (experimental study) |
publisher |
Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics |
series |
Гений oртопедии |
issn |
1028-4427 2542-131X |
publishDate |
2021-04-01 |
description |
Relevance Defects of long bones result in anatomical and functional complex of pathologies in the entire limb. There are few fundamental studies of tissues
adjacent to bone defects by using different technologies for management of long bone defects. Purpose To study the structural changes in the synovial
membrane of the knee joint by modelling the conditions for tibial defect management using the Ilizarov method of non-free bone plasty in combination with
the Masquelet technique. Materials and methods The conditions of post-resection defect of the tibia (from 15 % of the segment length) by lengthening the
distal fragment were modeled in ten mongrel dogs. Temporarily, for 30 days, a cement spacer was implanted into the post-resection defect gap. Upon its
removal, the intermediate fragment in the lower third of the leg was transported at a rate of 1 mm in 4 steps until complete contact of the bone fragments.
Histomorphometric studies of the synovium were carried out at the observation stages at the end of the fixation period (60 days) and after removing the
apparatus (30 days). Results Two types of changes were revealed in the synovium: changes of a destructive nature without synovitis (30 % of cases) and
with signs of synovitis (70 % of cases, 3 dogs had mild synovitis and 4 dogs had severe synovitis). Changes in the microvessels of the synovial membrane
in synovitis indicated impaired microcirculation, high activity of angiogenesis and the development of hypervascularization. Conclusion Experimental
management of the tibial bone defect by Ilizarov method in combination with the Masquelet technique revealed signs of synovitis of the knee joint in 70 %
of cases using histophorphometry methods. |
topic |
synovium morphometry lower leg defect non-free bone plasty ilizarov method masquelet technique |
work_keys_str_mv |
AT tatyanaastupina histomorphometricchangesinthesynovialmembraneofthekneejointincombineduseoftheilizarovnonfreeboneplastyandthemasquelettechniqueexperimentalstudy AT olgavdiuriagina histomorphometricchangesinthesynovialmembraneofthekneejointincombineduseoftheilizarovnonfreeboneplastyandthemasquelettechniqueexperimentalstudy AT denissmokhovikov histomorphometricchangesinthesynovialmembraneofthekneejointincombineduseoftheilizarovnonfreeboneplastyandthemasquelettechniqueexperimentalstudy AT yuliaastupina histomorphometricchangesinthesynovialmembraneofthekneejointincombineduseoftheilizarovnonfreeboneplastyandthemasquelettechniqueexperimentalstudy AT dmitryyuborzunov histomorphometricchangesinthesynovialmembraneofthekneejointincombineduseoftheilizarovnonfreeboneplastyandthemasquelettechniqueexperimentalstudy |
_version_ |
1721516975484567552 |