Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility
Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05537-2 |
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Mitchell J. Machiela Thomas G. P. Grünewald Didier Surdez Stephanie Reynaud Olivier Mirabeau Eric Karlins Rebeca Alba Rubio Sakina Zaidi Sandrine Grossetete-Lalami Stelly Ballet Eve Lapouble Valérie Laurence Jean Michon Gaelle Pierron Heinrich Kovar Nathalie Gaspar Udo Kontny Anna González-Neira Piero Picci Javier Alonso Ana Patino-Garcia Nadège Corradini Perrine Marec Bérard Neal D. Freedman Nathaniel Rothman Casey L. Dagnall Laurie Burdett Kristine Jones Michelle Manning Kathleen Wyatt Weiyin Zhou Meredith Yeager David G. Cox Robert N. Hoover Javed Khan Gregory T. Armstrong Wendy M. Leisenring Smita Bhatia Leslie L. Robison Andreas E. Kulozik Jennifer Kriebel Thomas Meitinger Markus Metzler Wolfgang Hartmann Konstantin Strauch Thomas Kirchner Uta Dirksen Lindsay M. Morton Lisa Mirabello Margaret A. Tucker Franck Tirode Stephen J. Chanock Olivier Delattre |
| spellingShingle |
Mitchell J. Machiela Thomas G. P. Grünewald Didier Surdez Stephanie Reynaud Olivier Mirabeau Eric Karlins Rebeca Alba Rubio Sakina Zaidi Sandrine Grossetete-Lalami Stelly Ballet Eve Lapouble Valérie Laurence Jean Michon Gaelle Pierron Heinrich Kovar Nathalie Gaspar Udo Kontny Anna González-Neira Piero Picci Javier Alonso Ana Patino-Garcia Nadège Corradini Perrine Marec Bérard Neal D. Freedman Nathaniel Rothman Casey L. Dagnall Laurie Burdett Kristine Jones Michelle Manning Kathleen Wyatt Weiyin Zhou Meredith Yeager David G. Cox Robert N. Hoover Javed Khan Gregory T. Armstrong Wendy M. Leisenring Smita Bhatia Leslie L. Robison Andreas E. Kulozik Jennifer Kriebel Thomas Meitinger Markus Metzler Wolfgang Hartmann Konstantin Strauch Thomas Kirchner Uta Dirksen Lindsay M. Morton Lisa Mirabello Margaret A. Tucker Franck Tirode Stephen J. Chanock Olivier Delattre Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility Nature Communications |
| author_facet |
Mitchell J. Machiela Thomas G. P. Grünewald Didier Surdez Stephanie Reynaud Olivier Mirabeau Eric Karlins Rebeca Alba Rubio Sakina Zaidi Sandrine Grossetete-Lalami Stelly Ballet Eve Lapouble Valérie Laurence Jean Michon Gaelle Pierron Heinrich Kovar Nathalie Gaspar Udo Kontny Anna González-Neira Piero Picci Javier Alonso Ana Patino-Garcia Nadège Corradini Perrine Marec Bérard Neal D. Freedman Nathaniel Rothman Casey L. Dagnall Laurie Burdett Kristine Jones Michelle Manning Kathleen Wyatt Weiyin Zhou Meredith Yeager David G. Cox Robert N. Hoover Javed Khan Gregory T. Armstrong Wendy M. Leisenring Smita Bhatia Leslie L. Robison Andreas E. Kulozik Jennifer Kriebel Thomas Meitinger Markus Metzler Wolfgang Hartmann Konstantin Strauch Thomas Kirchner Uta Dirksen Lindsay M. Morton Lisa Mirabello Margaret A. Tucker Franck Tirode Stephen J. Chanock Olivier Delattre |
| author_sort |
Mitchell J. Machiela |
| title |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_short |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_full |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_fullStr |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_full_unstemmed |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_sort |
genome-wide association study identifies multiple new loci associated with ewing sarcoma susceptibility |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis. |
| url |
https://doi.org/10.1038/s41467-018-05537-2 |
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doaj-0ac8edbb89d948f498acb3404c1156e82021-05-11T10:27:41ZengNature Publishing GroupNature Communications2041-17232018-08-01911810.1038/s41467-018-05537-2Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibilityMitchell J. Machiela0Thomas G. P. Grünewald1Didier Surdez2Stephanie Reynaud3Olivier Mirabeau4Eric Karlins5Rebeca Alba Rubio6Sakina Zaidi7Sandrine Grossetete-Lalami8Stelly Ballet9Eve Lapouble10Valérie Laurence11Jean Michon12Gaelle Pierron13Heinrich Kovar14Nathalie Gaspar15Udo Kontny16Anna González-Neira17Piero Picci18Javier Alonso19Ana Patino-Garcia20Nadège Corradini21Perrine Marec Bérard22Neal D. Freedman23Nathaniel Rothman24Casey L. Dagnall25Laurie Burdett26Kristine Jones27Michelle Manning28Kathleen Wyatt29Weiyin Zhou30Meredith Yeager31David G. Cox32Robert N. Hoover33Javed Khan34Gregory T. Armstrong35Wendy M. Leisenring36Smita Bhatia37Leslie L. Robison38Andreas E. Kulozik39Jennifer Kriebel40Thomas Meitinger41Markus Metzler42Wolfgang Hartmann43Konstantin Strauch44Thomas Kirchner45Uta Dirksen46Lindsay M. Morton47Lisa Mirabello48Margaret A. Tucker49Franck Tirode50Stephen J. Chanock51Olivier Delattre52Division of Cancer Epidemiology and Genetics, National Cancer InstituteMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMUInserm U830, Équipe Labellisés LNCC, PSL Université, Institut CurieSIREDO Oncology Centre, Institut CurieInserm U830, Équipe Labellisés LNCC, PSL Université, Institut CurieDivision of Cancer Epidemiology and Genetics, National Cancer InstituteMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMUInserm U830, Équipe Labellisés LNCC, PSL Université, Institut CurieInserm U830, Équipe Labellisés LNCC, PSL Université, Institut CurieSIREDO Oncology Centre, Institut CurieSIREDO Oncology Centre, Institut CurieSIREDO Oncology Centre, Institut CurieSIREDO Oncology Centre, Institut CurieSIREDO Oncology Centre, Institut CurieChildren’s Cancer Research Institute, St. Anna KinderkrebsforschungDepartment of Oncology for Child and Adolescent, Institut Gustave RoussyDivision of Pediatric Hematology Oncology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen UniversityHuman Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research CentreLaboratorio di Oncologia Sperimentale, Istituto Ortopedico Rizzoli di BolognaUnidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos IIILaboratory of Pediatrics, University of Navarra, University Clinic of Navarra, IdiSNAInstitute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of LyonInstitute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of LyonDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteCentre Léon Bérard, INSERM U1052Division of Cancer Epidemiology and Genetics, National Cancer InstituteGenetics Branch, Center for Cancer Research, National Cancer InstituteDepartment of Epidemiology and Cancer Control, St. Jude Children’s Research HospitalCancer Prevention and Clinical Statistics Programs, Fred Hutchinson Cancer Research CenterInstitute for Cancer Outcomes and Survivorship, University of AlabamaDepartment of Epidemiology and Cancer Control, St. Jude Children’s Research HospitalUniversity Children’s Hospital of HeidelbergResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental HealthUniversity Children’s Hospital of ErlangenGerhard-Domagk Institute of Pathology, University Hospital of MünsterInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthGerman Consortium for Cancer Research (DKTK)University Children’s Hospital of EssenDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteInserm U830, Équipe Labellisés LNCC, PSL Université, Institut CurieDivision of Cancer Epidemiology and Genetics, National Cancer InstituteInserm U830, Équipe Labellisés LNCC, PSL Université, Institut CurieEwing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.https://doi.org/10.1038/s41467-018-05537-2 |