Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta‐analysis
Abstract Introduction IDH1/2 mutations are prevalent in cartilaginous tumors including chondrosarcoma. This meta‐analysis using individual patient data (IPD) aimed to investigate the clinical and prognostic association of these mutations in chondrosarcoma patients. Methods Two electronic databases i...
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doaj-0af66dc034784682b73bc0193a5f578c2021-07-09T04:54:54ZengWileyCancer Medicine2045-76342021-07-0110134415442310.1002/cam4.4019Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta‐analysisHuy Gia Vuong0Tam N.M. Ngo1Ian F. Dunn2Department of Pathology Oklahoma University Health Sciences Center Oklahoma City OK USAFaculty of Medicine Pham Ngoc Thach University of Medicine Ho Chi Minh City VietnamDepartment of Neurosurgery Oklahoma University Health Sciences Center Oklahoma City OK USAAbstract Introduction IDH1/2 mutations are prevalent in cartilaginous tumors including chondrosarcoma. This meta‐analysis using individual patient data (IPD) aimed to investigate the clinical and prognostic association of these mutations in chondrosarcoma patients. Methods Two electronic databases including PubMed and Web of Science were searched for relevant data. We included studies providing IPD of chondrosarcoma with available IDH1/2 mutational status for meta‐analysis. Chi‐square and t‐test were performed to compare the groups with and without IDH1/2 mutations. For survival analysis, log‐rank test, and Cox proportional hazards model were used to investigate the association of IDH mutations with patient outcomes. Results Fourteen studies with 488 patients were analyzed. IDH1 and IDH2 mutations were detected in 38.7% and 12.1% of cases, respectively. IDH1/2 mutations were significantly associated with an older age (p = 0.003), tumor origins (p < 0.001), tumor grades (p < 0.001), larger diameter (p = 0.003), relapse (p = 0.014), and patient mortality (p = 0.04). Multivariate Cox regression analysis adjusted for age, gender, tumor grade, and tumor sites confirmed the negative impact of IDH1/2 mutations on patient overall survival (HR = 1.90; 95% CI = 1.06–3.42; p = 0.03). Conclusion Our meta‐analysis demonstrated the distinct characteristics of IDH1/2‐mutated chondrosarcomas in comparison to those without mutations. These mutations could serve as an independent prognostic biomarker to better prognosticate patient outcomes and design appropriate treatment plans.https://doi.org/10.1002/cam4.4019chondrosarcomaIDHisocitrate dehydrogenasemeta‐analysisoverall survivalrecurrence‐free survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huy Gia Vuong Tam N.M. Ngo Ian F. Dunn |
spellingShingle |
Huy Gia Vuong Tam N.M. Ngo Ian F. Dunn Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta‐analysis Cancer Medicine chondrosarcoma IDH isocitrate dehydrogenase meta‐analysis overall survival recurrence‐free survival |
author_facet |
Huy Gia Vuong Tam N.M. Ngo Ian F. Dunn |
author_sort |
Huy Gia Vuong |
title |
Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta‐analysis |
title_short |
Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta‐analysis |
title_full |
Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta‐analysis |
title_fullStr |
Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta‐analysis |
title_full_unstemmed |
Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta‐analysis |
title_sort |
prognostic importance of idh mutations in chondrosarcoma: an individual patient data meta‐analysis |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2021-07-01 |
description |
Abstract Introduction IDH1/2 mutations are prevalent in cartilaginous tumors including chondrosarcoma. This meta‐analysis using individual patient data (IPD) aimed to investigate the clinical and prognostic association of these mutations in chondrosarcoma patients. Methods Two electronic databases including PubMed and Web of Science were searched for relevant data. We included studies providing IPD of chondrosarcoma with available IDH1/2 mutational status for meta‐analysis. Chi‐square and t‐test were performed to compare the groups with and without IDH1/2 mutations. For survival analysis, log‐rank test, and Cox proportional hazards model were used to investigate the association of IDH mutations with patient outcomes. Results Fourteen studies with 488 patients were analyzed. IDH1 and IDH2 mutations were detected in 38.7% and 12.1% of cases, respectively. IDH1/2 mutations were significantly associated with an older age (p = 0.003), tumor origins (p < 0.001), tumor grades (p < 0.001), larger diameter (p = 0.003), relapse (p = 0.014), and patient mortality (p = 0.04). Multivariate Cox regression analysis adjusted for age, gender, tumor grade, and tumor sites confirmed the negative impact of IDH1/2 mutations on patient overall survival (HR = 1.90; 95% CI = 1.06–3.42; p = 0.03). Conclusion Our meta‐analysis demonstrated the distinct characteristics of IDH1/2‐mutated chondrosarcomas in comparison to those without mutations. These mutations could serve as an independent prognostic biomarker to better prognosticate patient outcomes and design appropriate treatment plans. |
topic |
chondrosarcoma IDH isocitrate dehydrogenase meta‐analysis overall survival recurrence‐free survival |
url |
https://doi.org/10.1002/cam4.4019 |
work_keys_str_mv |
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