A System Dynamics Model to Predict the Human Monocyte Response to Endotoxins

A System Dynamics Model to Predict the Human Monocyte Response to Endotoxins

System dynamics is a powerful tool that allows modeling of complex and highly networked systems such as those found in the human immune system. We have developed a model that reproduces how the exposure of human monocytes to lipopolysaccharides (LPSs) induces an inflammatory state characterized by h...

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Bibliographic Details
Main Authors: Enrique Álvarez, Víctor Toledano, Fernando Morilla, Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Aníbal Varela-Serrano, José Casas-Martín, José Avendaño-Ortiz, Luis A. Aguirre, Francisco Arnalich, Charbel Maroun-Eid, Alejandro Martín-Quirós, Manuel Quintana Díaz, Eduardo López-Collazo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
monocytes
endotoxin tolerance
inflammation
bacterial lipopolysaccharide
mathematical model
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00915/full

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