Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma
This study aimed to compare the oncological and renal outcomes of partial ureterectomy (PU) versus radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). UTUC patients’ clinical information was reviewed, and progression-free survival (PFS), overall survival (OS), and kidney fu...
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2018-01-01
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Online Access: | http://dx.doi.org/10.1155/2018/2793172 |
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doaj-0b19234e69044c85a6d4a0748c4ac8a42020-11-24T22:44:11ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/27931722793172Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial CarcinomaJianzhong Zhang0Feiya Yang1Mingshuai Wang2Yinong Niu3Weicheng Chen4Nianzeng Xing5Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaThis study aimed to compare the oncological and renal outcomes of partial ureterectomy (PU) versus radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). UTUC patients’ clinical information was reviewed, and progression-free survival (PFS), overall survival (OS), and kidney function were collected. The mean follow-up period was 59 (6–135) months in the RNU group and 34.5 (5–135) months in the PU group. The mean operation time in the PU group was 141 (64–340) min, which is significantly shorter than the RNU group (P<0.01). Regarding kidney function at one year or two years after operation, the PU group had significantly improved mean estimated glomerular filtration rate (eGFR) levels and a remarkably decreased constitution of patients with chronic kidney disease (CKD) III or higher group (P<0.05). There was no significant difference in PFS and OS between the RNU group and the PU group (P>0.05). Multifactor Cox regression analysis indicated that age and the preoperative CKD stages were independent risk factors for poor kidney functions of UTUC patients. Compared to patients in RNU group, patients in PU have no significant difference in survival time but have shorter operation time, shorter hospital stay, and improved kidney functions.http://dx.doi.org/10.1155/2018/2793172 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jianzhong Zhang Feiya Yang Mingshuai Wang Yinong Niu Weicheng Chen Nianzeng Xing |
spellingShingle |
Jianzhong Zhang Feiya Yang Mingshuai Wang Yinong Niu Weicheng Chen Nianzeng Xing Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma BioMed Research International |
author_facet |
Jianzhong Zhang Feiya Yang Mingshuai Wang Yinong Niu Weicheng Chen Nianzeng Xing |
author_sort |
Jianzhong Zhang |
title |
Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma |
title_short |
Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma |
title_full |
Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma |
title_fullStr |
Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma |
title_full_unstemmed |
Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma |
title_sort |
comparison of radical nephroureterectomy and partial ureterectomy for the treatment of upper tract urothelial carcinoma |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2018-01-01 |
description |
This study aimed to compare the oncological and renal outcomes of partial ureterectomy (PU) versus radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). UTUC patients’ clinical information was reviewed, and progression-free survival (PFS), overall survival (OS), and kidney function were collected. The mean follow-up period was 59 (6–135) months in the RNU group and 34.5 (5–135) months in the PU group. The mean operation time in the PU group was 141 (64–340) min, which is significantly shorter than the RNU group (P<0.01). Regarding kidney function at one year or two years after operation, the PU group had significantly improved mean estimated glomerular filtration rate (eGFR) levels and a remarkably decreased constitution of patients with chronic kidney disease (CKD) III or higher group (P<0.05). There was no significant difference in PFS and OS between the RNU group and the PU group (P>0.05). Multifactor Cox regression analysis indicated that age and the preoperative CKD stages were independent risk factors for poor kidney functions of UTUC patients. Compared to patients in RNU group, patients in PU have no significant difference in survival time but have shorter operation time, shorter hospital stay, and improved kidney functions. |
url |
http://dx.doi.org/10.1155/2018/2793172 |
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