Clinically unsuspected Hodgkin′s lymphoma diagnosed primarily from bone marrow trephine biopsy: Report of six cases
Bone marrow may be the initial or rarely the only site of involvement in Hodgkin′s lymphoma. A high index of suspicion is required to pick up the histopathological changes of Hodgkin′s lesions in the bone marrow like necrosis, presence of Reed-Sternberg cell or its variant in a...
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Wolters Kluwer Medknow Publications
2008-04-01
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doaj-0b1ecd623b944c399e9809e603b3b5892020-11-24T23:52:16ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292008-04-01512186189Clinically unsuspected Hodgkin′s lymphoma diagnosed primarily from bone marrow trephine biopsy: Report of six casesKar RakheeDutta ShyamaliTyagi SeemaBone marrow may be the initial or rarely the only site of involvement in Hodgkin′s lymphoma. A high index of suspicion is required to pick up the histopathological changes of Hodgkin′s lesions in the bone marrow like necrosis, presence of Reed-Sternberg cell or its variant in a polymorphic background infiltrate, focal fibrosis and myxoid change especially in the absence of classical clinical picture. Bone marrow with immunohistochemistry has a valuable role in the staging and in the diagnosis of primary medullary Hodgkin′s lymphoma. B-symptoms may easily masquerade as an infectious process as in all our cases the patients had fever as a presenting feature, in four of them tuberculosis was suspected clinically and two had received antitubercular therapy elsewhere. We report six human immunodeficiency virus-negative patients diagnosed over a period of 5 years in which the initial diagnosis of Hodgkin′s lymphoma was suggested from bone marrow histology.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2008;volume=51;issue=2;spage=186;epage=189;aulast=KarBone marrowHodgkin′s lymphomatrephine biopsy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kar Rakhee Dutta Shyamali Tyagi Seema |
spellingShingle |
Kar Rakhee Dutta Shyamali Tyagi Seema Clinically unsuspected Hodgkin′s lymphoma diagnosed primarily from bone marrow trephine biopsy: Report of six cases Indian Journal of Pathology and Microbiology Bone marrow Hodgkin′s lymphoma trephine biopsy |
author_facet |
Kar Rakhee Dutta Shyamali Tyagi Seema |
author_sort |
Kar Rakhee |
title |
Clinically unsuspected Hodgkin′s lymphoma diagnosed primarily from bone marrow trephine biopsy: Report of six cases |
title_short |
Clinically unsuspected Hodgkin′s lymphoma diagnosed primarily from bone marrow trephine biopsy: Report of six cases |
title_full |
Clinically unsuspected Hodgkin′s lymphoma diagnosed primarily from bone marrow trephine biopsy: Report of six cases |
title_fullStr |
Clinically unsuspected Hodgkin′s lymphoma diagnosed primarily from bone marrow trephine biopsy: Report of six cases |
title_full_unstemmed |
Clinically unsuspected Hodgkin′s lymphoma diagnosed primarily from bone marrow trephine biopsy: Report of six cases |
title_sort |
clinically unsuspected hodgkin′s lymphoma diagnosed primarily from bone marrow trephine biopsy: report of six cases |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Pathology and Microbiology |
issn |
0377-4929 |
publishDate |
2008-04-01 |
description |
Bone marrow may be the initial or rarely the only site of involvement in Hodgkin′s lymphoma. A high index of suspicion is required to pick up the histopathological changes of Hodgkin′s lesions in the bone marrow like necrosis, presence of Reed-Sternberg cell or its variant in a polymorphic background infiltrate, focal fibrosis and myxoid change especially in the absence of classical clinical picture. Bone marrow with immunohistochemistry has a valuable role in the staging and in the diagnosis of primary medullary Hodgkin′s lymphoma. B-symptoms may easily masquerade as an infectious process as in all our cases the patients had fever as a presenting feature, in four of them tuberculosis was suspected clinically and two had received antitubercular therapy elsewhere. We report six human immunodeficiency virus-negative patients diagnosed over a period of 5 years in which the initial diagnosis of Hodgkin′s lymphoma was suggested from bone marrow histology. |
topic |
Bone marrow Hodgkin′s lymphoma trephine biopsy |
url |
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2008;volume=51;issue=2;spage=186;epage=189;aulast=Kar |
work_keys_str_mv |
AT karrakhee clinicallyunsuspectedhodgkinx2032slymphomadiagnosedprimarilyfrombonemarrowtrephinebiopsyreportofsixcases AT duttashyamali clinicallyunsuspectedhodgkinx2032slymphomadiagnosedprimarilyfrombonemarrowtrephinebiopsyreportofsixcases AT tyagiseema clinicallyunsuspectedhodgkinx2032slymphomadiagnosedprimarilyfrombonemarrowtrephinebiopsyreportofsixcases |
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1725473998741962752 |