Relationship of Inflammatory Cytokines From M1-Type Microglia/Macrophages at the Injured Site and Lumbar Enlargement With Neuropathic Pain After Spinal Cord Injury in the CCL21 Knockout (plt) Mouse

Relationship of Inflammatory Cytokines From M1-Type Microglia/Macrophages at the Injured Site and Lumbar Enlargement With Neuropathic Pain After Spinal Cord Injury in the CCL21 Knockout (plt) Mouse

Spinal cord injury (SCI) causes loss of normal sensation and often leads to debilitating neuropathic pain (NeP). Chronic NeP develops at or below the SCI lesion in as many as 80% of patients with SCI and may be induced by modulators of neuronal excitability released from activated microglia and macr...

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Bibliographic Details
Main Authors: Kazuya Honjoh, Hideaki Nakajima, Takayuki Hirai, Shuji Watanabe, Akihiko Matsumine
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CCL21
neuropathic pain
spinal cord injury
macrophage
microglia
M1/M2 phenotype
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00525/full

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