Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002–2010
Group A Streptococcus (GAS) is a human-adapted pathogen that causes a variety of diseases, including pharyngitis and invasive infections. GAS strains are categorized by variation in the nucleotide sequence of the gene (emm) that encodes the M protein. To identify the emm types of GAS strains causing...
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Centers for Disease Control and Prevention
2011-11-01
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doaj-0b314774718046cf8d6e0168ce57b21e2020-11-25T01:04:37ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592011-11-0117112010201710.3201/eid1711.110159Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002–2010Patrick R. SheaAmy L. EwbankJavier H. Gonzalez-LugoAlexandro J. Martagon-RosadoJuan C. Martinez-GutierrezHina A. RehmanMonica Serrano-GonzalezNahuel FittipaldiStephen B. BeresAnthony R. FloresDonald E. LowBarbara M. WilleyJames M. MusserGroup A Streptococcus (GAS) is a human-adapted pathogen that causes a variety of diseases, including pharyngitis and invasive infections. GAS strains are categorized by variation in the nucleotide sequence of the gene (emm) that encodes the M protein. To identify the emm types of GAS strains causing pharyngitis in Ontario, Canada, we sequenced the hypervariable region of the emm gene in 4,635 pharyngeal GAS isolates collected during 2002–2010. The most prevalent emm types varied little from year to year. In contrast, fine-scale geographic analysis identified inter-site variability in the most common emm types. Additionally, we observed fluctuations in yearly frequency of emm3 strains from pharyngitis patients that coincided with peaks of emm3 invasive infections. We also discovered a striking increase in frequency of emm89 strains among isolates from patients with pharyngitis and invasive disease. These findings about the epidemiology of GAS are potentially useful for vaccine research.https://wwwnc.cdc.gov/eid/article/17/11/11-0159_articleStreptococcus pyogenesGASpharyngitisgroup A streptococcusCanadaemm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patrick R. Shea Amy L. Ewbank Javier H. Gonzalez-Lugo Alexandro J. Martagon-Rosado Juan C. Martinez-Gutierrez Hina A. Rehman Monica Serrano-Gonzalez Nahuel Fittipaldi Stephen B. Beres Anthony R. Flores Donald E. Low Barbara M. Willey James M. Musser |
spellingShingle |
Patrick R. Shea Amy L. Ewbank Javier H. Gonzalez-Lugo Alexandro J. Martagon-Rosado Juan C. Martinez-Gutierrez Hina A. Rehman Monica Serrano-Gonzalez Nahuel Fittipaldi Stephen B. Beres Anthony R. Flores Donald E. Low Barbara M. Willey James M. Musser Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002–2010 Emerging Infectious Diseases Streptococcus pyogenes GAS pharyngitis group A streptococcus Canada emm |
author_facet |
Patrick R. Shea Amy L. Ewbank Javier H. Gonzalez-Lugo Alexandro J. Martagon-Rosado Juan C. Martinez-Gutierrez Hina A. Rehman Monica Serrano-Gonzalez Nahuel Fittipaldi Stephen B. Beres Anthony R. Flores Donald E. Low Barbara M. Willey James M. Musser |
author_sort |
Patrick R. Shea |
title |
Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002–2010 |
title_short |
Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002–2010 |
title_full |
Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002–2010 |
title_fullStr |
Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002–2010 |
title_full_unstemmed |
Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002–2010 |
title_sort |
group a streptococcus emm gene types in pharyngeal isolates, ontario, canada, 2002–2010 |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2011-11-01 |
description |
Group A Streptococcus (GAS) is a human-adapted pathogen that causes a variety of diseases, including pharyngitis and invasive infections. GAS strains are categorized by variation in the nucleotide sequence of the gene (emm) that encodes the M protein. To identify the emm types of GAS strains causing pharyngitis in Ontario, Canada, we sequenced the hypervariable region of the emm gene in 4,635 pharyngeal GAS isolates collected during 2002–2010. The most prevalent emm types varied little from year to year. In contrast, fine-scale geographic analysis identified inter-site variability in the most common emm types. Additionally, we observed fluctuations in yearly frequency of emm3 strains from pharyngitis patients that coincided with peaks of emm3 invasive infections. We also discovered a striking increase in frequency of emm89 strains among isolates from patients with pharyngitis and invasive disease. These findings about the epidemiology of GAS are potentially useful for vaccine research. |
topic |
Streptococcus pyogenes GAS pharyngitis group A streptococcus Canada emm |
url |
https://wwwnc.cdc.gov/eid/article/17/11/11-0159_article |
work_keys_str_mv |
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