Prostaglandin E2 Stimulates the Expansion of Regulatory Hematopoietic Stem and Progenitor Cells in Type 1 Diabetes

Prostaglandin E2 Stimulates the Expansion of Regulatory Hematopoietic Stem and Progenitor Cells in Type 1 Diabetes

Hematopoietic stem and progenitor cells (HSPCs) are multipotent stem cells that have been harnessed as a curative therapy for patients with hematological malignancies. Notably, the discovery that HSPCs are endowed with immunoregulatory properties suggests that HSPC-based therapeutic approaches may b...

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Bibliographic Details
Main Authors: Moufida Ben Nasr, Francesca D’Addio, Amir Mohammad Malvandi, Silvia Faravelli, Eduardo Castillo-Leon, Vera Usuelli, Francesca Rocchio, Teresa Letizia, Abdel Basset El Essawy, Emma Assi, Chiara Mameli, Elisa Giani, Maddalena Macedoni, Anna Maestroni, Alice Dassano, Cristian Loretelli, Moira Paroni, Giuseppe Cannalire, Giacomo Biasucci, Marco Sala, Alessandra Biffi, Gian Vincenzo Zuccotti, Paolo Fiorina
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
hematopoietic stem and progenitor cells
prostaglandins
autoimmune diseases
PD-L1
CXCR4
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01387/full

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