Structural Features of Antitumor Titanium Agents and Related Compounds
Previous studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Parti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2005-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/BCA.2005.317 |
| Summary: | Previous studies established some Ti compounds as having marked activity against tumors of the
gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent
structural features of known antitumor Ti agents and other potentially active compounds. Particularly
noteworthy features are that Ti-O bonds are short and Ti-O-Ti bond angles are large, demonstrating that in
these compounds the O binding has high s-character approaching sp hybridization. |
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| ISSN: | 1565-3633 |