Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is...
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doaj-0b3a0e6c6fb5407d8248a229026fc26b2021-01-10T00:02:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-012261461410.3390/ijms22020614Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked AssociationGiandomenico Bisaccia0Fabrizio Ricci1Sabina Gallina2Angela Di Baldassarre3Barbara Ghinassi4MIUR Department of Excellence, Department of Neuroscience, Imaging and Clinical Sciences, University “G.d’Annunzio” of Chieti-Pescara, Via Luigi Polacchi, 11-66100 Chieti, ItalyMIUR Department of Excellence, Department of Neuroscience, Imaging and Clinical Sciences, University “G.d’Annunzio” of Chieti-Pescara, Via Luigi Polacchi, 11-66100 Chieti, ItalyMIUR Department of Excellence, Department of Neuroscience, Imaging and Clinical Sciences, University “G.d’Annunzio” of Chieti-Pescara, Via Luigi Polacchi, 11-66100 Chieti, ItalyDepartment of Medicine and Aging Sciences, University “G.d’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Medicine and Aging Sciences, University “G.d’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyThe myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the contribution of mitochondrial dysfunction to multiple cardiac disease phenotypes and their transition to heart failure; and (iii) discuss the rationale and current evidence for targeting mitochondrial function for the treatment of heart failure, including via sodium-glucose cotransporter 2 inhibitors.https://www.mdpi.com/1422-0067/22/2/614mitochondriaheart failuremitochondrial dynamicscardiomyopathycardiac energetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giandomenico Bisaccia Fabrizio Ricci Sabina Gallina Angela Di Baldassarre Barbara Ghinassi |
spellingShingle |
Giandomenico Bisaccia Fabrizio Ricci Sabina Gallina Angela Di Baldassarre Barbara Ghinassi Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association International Journal of Molecular Sciences mitochondria heart failure mitochondrial dynamics cardiomyopathy cardiac energetics |
author_facet |
Giandomenico Bisaccia Fabrizio Ricci Sabina Gallina Angela Di Baldassarre Barbara Ghinassi |
author_sort |
Giandomenico Bisaccia |
title |
Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association |
title_short |
Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association |
title_full |
Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association |
title_fullStr |
Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association |
title_full_unstemmed |
Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association |
title_sort |
mitochondrial dysfunction and heart disease: critical appraisal of an overlooked association |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-01-01 |
description |
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the contribution of mitochondrial dysfunction to multiple cardiac disease phenotypes and their transition to heart failure; and (iii) discuss the rationale and current evidence for targeting mitochondrial function for the treatment of heart failure, including via sodium-glucose cotransporter 2 inhibitors. |
topic |
mitochondria heart failure mitochondrial dynamics cardiomyopathy cardiac energetics |
url |
https://www.mdpi.com/1422-0067/22/2/614 |
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