NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices
To develop multifunctional delivery systems of targeted properties for biomedical applications, hybrid fiber-nanoparticle matrices capable of controlled and monitored nanoparticles (NPs) delivery properties were prepared. Firstly, electropinning technique was applied to produce carbon nanotubes (CNT...
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doaj-0b4464df0ff6491aadbf9cbaef29ef0a2020-11-25T02:52:02ZengElsevierMaterials Today Advances2590-04982020-06-016NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matricesG. Cao0Y. Li1Y. Qi2Y. Qiao3J. He4H. Zhang5W. Cui6M. Zhou7Department of Radiology, Shulan (Hang Zhou) Hospital, Hangzhou 310000, ChinaInstitute of Translational Medicine, Zhejiang University, Hangzhou, 310009, China; Key Laboratory of Cancer Prevention and Intervention (Ministry of Education), Zhejiang University, Hangzhou, 310009, China; Corresponding author.Institute of Translational Medicine, Zhejiang University, Hangzhou, 310009, ChinaInstitute of Translational Medicine, Zhejiang University, Hangzhou, 310009, ChinaInstitute of Translational Medicine, Zhejiang University, Hangzhou, 310009, ChinaDepartment of Pharmaceutical Science Laboratory, Åbo Akademi University, Turku, 20520, Finland; Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China; Corresponding author.Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China; Corresponding author.Institute of Translational Medicine, Zhejiang University, Hangzhou, 310009, China; Key Laboratory of Cancer Prevention and Intervention (Ministry of Education), Zhejiang University, Hangzhou, 310009, China; Corresponding author.To develop multifunctional delivery systems of targeted properties for biomedical applications, hybrid fiber-nanoparticle matrices capable of controlled and monitored nanoparticles (NPs) delivery properties were prepared. Firstly, electropinning technique was applied to produce carbon nanotubes (CNTs) incorporated biodegradable poly(ϵ-caprolactone)/gelatin (PG) polymer fibers (PGC fibers). Subsequently, the photoluminescent mesoporous silica nanoparticles (PLMSNs) were electrostatically attached on the surface of PGC fibers to form a localized delivery platform. The PGC-PLMSNs fibers can emit red light under excitation at ~395 nm, 465 nm, and ~533 nm. Additionally, under NIR (808 nm) irradiation, PGC-PLMSNs fibers revealed good photothermal effect. PLMSNs loading efficiency onto the PGC fibers and PLMSNs release kinetics were assessed by TG method. More importantly, the 808 nm NIR irradiation enabled remarkably promoted PLMSNs release rate, validating the typical NIR-triggered release properties. Meanwhile, PLMSNs released from the composite fibers could be optically monitored by decrease in the intensity of red emission. These results suggest the possibility to develop the localized therapeutic device that may inspire other means of treatment method for cancer therapy.http://www.sciencedirect.com/science/article/pii/S2590049819301183Electrospun fiberLocalized deliveryNIR-triggered releaseOptically monitoredCarbon nanotubes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
G. Cao Y. Li Y. Qi Y. Qiao J. He H. Zhang W. Cui M. Zhou |
spellingShingle |
G. Cao Y. Li Y. Qi Y. Qiao J. He H. Zhang W. Cui M. Zhou NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices Materials Today Advances Electrospun fiber Localized delivery NIR-triggered release Optically monitored Carbon nanotubes |
author_facet |
G. Cao Y. Li Y. Qi Y. Qiao J. He H. Zhang W. Cui M. Zhou |
author_sort |
G. Cao |
title |
NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices |
title_short |
NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices |
title_full |
NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices |
title_fullStr |
NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices |
title_full_unstemmed |
NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices |
title_sort |
nir-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices |
publisher |
Elsevier |
series |
Materials Today Advances |
issn |
2590-0498 |
publishDate |
2020-06-01 |
description |
To develop multifunctional delivery systems of targeted properties for biomedical applications, hybrid fiber-nanoparticle matrices capable of controlled and monitored nanoparticles (NPs) delivery properties were prepared. Firstly, electropinning technique was applied to produce carbon nanotubes (CNTs) incorporated biodegradable poly(ϵ-caprolactone)/gelatin (PG) polymer fibers (PGC fibers). Subsequently, the photoluminescent mesoporous silica nanoparticles (PLMSNs) were electrostatically attached on the surface of PGC fibers to form a localized delivery platform. The PGC-PLMSNs fibers can emit red light under excitation at ~395 nm, 465 nm, and ~533 nm. Additionally, under NIR (808 nm) irradiation, PGC-PLMSNs fibers revealed good photothermal effect. PLMSNs loading efficiency onto the PGC fibers and PLMSNs release kinetics were assessed by TG method. More importantly, the 808 nm NIR irradiation enabled remarkably promoted PLMSNs release rate, validating the typical NIR-triggered release properties. Meanwhile, PLMSNs released from the composite fibers could be optically monitored by decrease in the intensity of red emission. These results suggest the possibility to develop the localized therapeutic device that may inspire other means of treatment method for cancer therapy. |
topic |
Electrospun fiber Localized delivery NIR-triggered release Optically monitored Carbon nanotubes |
url |
http://www.sciencedirect.com/science/article/pii/S2590049819301183 |
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