Viral FLIP blocks Caspase-8 driven apoptosis in the gut in vivo.

A strict cell death control in the intestinal epithelium is indispensable to maintain barrier integrity and homeostasis. In order to achieve a balance between cell proliferation and cell death, a tight regulation of Caspase-8, which is a key player in controlling apoptosis, is required. Caspase-8 ac...

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Bibliographic Details
Main Authors: Barbara Ruder, Claudia Günther, Michael Stürzl, Markus Friedrich Neurath, Ethel Cesarman, Gianna Ballon, Christoph Becker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228441

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