Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.
(+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+)-SKF 10047 inhibits K(+), Na(+) and Ca2+ channels via sigma-1 receptor activation. We found that (+)-SKF 10047 inhibited Na(V)1.2...
Main Authors: | Xiao-Fei Gao, Jin-Jing Yao, Yan-Lin He, Changlong Hu, Yan-Ai Mei |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3489664?pdf=render |
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