Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form

Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form

An inert matrix  that is used to control the release of  (PTX) was prepared using Eudragit RL100 and RSPM types as matrix forming agent . The matrices were prepared by either dry granulation(slugging) , or wet granulation method using chloroform as a solvent evaporation vehichle. The cumulative rel...

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Main Authors: Ahmed H. Hussain, Yehia I.Khalil
Format: Article
Language:English
Published: College of Pharmacy University of Baghdad 2017-03-01
Series:Iraqi Journal of Pharmaceutical Sciences
Online Access:https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/571
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spelling doaj-0b52ab112f40499fa5037af576a4c7cb2021-06-20T10:10:23ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972017-03-0117110.31351/vol17iss1pp1-6Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage FormAhmed H. HussainYehia I.Khalil An inert matrix  that is used to control the release of  (PTX) was prepared using Eudragit RL100 and RSPM types as matrix forming agent . The matrices were prepared by either dry granulation(slugging) , or wet granulation method using chloroform as a solvent evaporation vehichle. The cumulative release was adjusted by using polyvinylpyrollidone (PVP) or ethylcellulose (EC) polymers .The results indicated that   both methods of preparation were valid for incorporation PTX as a sustained release granules .Moreover ,the results revealed that best polymer used  was Eudragit RSPM in 3:20 polymer drug ratio .Besides to that ,   the results indicated that the release profiles were affected by  pH- medium  , PVP and EC addition as an enhancer or retardant polymer used respectively. As well as to the method of preparation . Key words :  Pentoxifylline  Sustained Retease ,  Eudragit  RS , RL . https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/571
collection DOAJ
language English
format Article
sources DOAJ
author Ahmed H. Hussain
Yehia I.Khalil
spellingShingle Ahmed H. Hussain
Yehia I.Khalil
Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form
Iraqi Journal of Pharmaceutical Sciences
author_facet Ahmed H. Hussain
Yehia I.Khalil
author_sort Ahmed H. Hussain
title Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form
title_short Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form
title_full Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form
title_fullStr Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form
title_full_unstemmed Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form
title_sort some variables affecting the formulation of pentoxifylline (ptx) as a solid sustained release dosage form
publisher College of Pharmacy University of Baghdad
series Iraqi Journal of Pharmaceutical Sciences
issn 2521-3512
1683-3597
publishDate 2017-03-01
description An inert matrix  that is used to control the release of  (PTX) was prepared using Eudragit RL100 and RSPM types as matrix forming agent . The matrices were prepared by either dry granulation(slugging) , or wet granulation method using chloroform as a solvent evaporation vehichle. The cumulative release was adjusted by using polyvinylpyrollidone (PVP) or ethylcellulose (EC) polymers .The results indicated that   both methods of preparation were valid for incorporation PTX as a sustained release granules .Moreover ,the results revealed that best polymer used  was Eudragit RSPM in 3:20 polymer drug ratio .Besides to that ,   the results indicated that the release profiles were affected by  pH- medium  , PVP and EC addition as an enhancer or retardant polymer used respectively. As well as to the method of preparation . Key words :  Pentoxifylline  Sustained Retease ,  Eudragit  RS , RL .
url https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/571
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AT yehiaikhalil somevariablesaffectingtheformulationofpentoxifyllineptxasasolidsustainedreleasedosageform
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