Elaboration of indirect method (test) for determination of enantiomeric purity of chiral PANAM (polyamide nucleic acids mimetics) monomers

Elaboration of indirect method (test) for determination of enantiomeric purity of chiral PANAM (polyamide nucleic acids mimetics) monomers

An indirect approach for the determination of enantiomeric purity of chiral α-(benzyl)-carboxyethyl- and γ-methyl-substituted monomers of polyamide nucleic acids mimics (PANAM) is described. The test consist in the synthesis of C-terminal diastereomers with methyl ester of L- or DL-isoleucine for ea...

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Bibliographic Details
Main Authors: Yu. G. Kirillova, A. V. Ryakin, D. I. Prokhorov, M. A. Lyanov, O. V. Esipova, S. V. Eremin, E. E. Zvonkova
Format: Article
Language:Russian
Published: MIREA - Russian Technological University 2012-04-01
Series:Тонкие химические технологии
Subjects:
peptide nucleic acids (pna)
polyamide nucleic acids mimics (panam)
chiral monomers
enantiomeric purity
reverse phase hplc
<sup><i>1</sup>н-nmr-spectroscopy
Online Access:https://www.finechem-mirea.ru/jour/article/view/758

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