The Development of Biocatalysis as a Tool for Drug Discovery
Enzymes are versatile biocatalysts capable of performing selective reactions. The advantages of enzymes in comparison to classical chemistry including chemical catalysts are the generally milder process conditions and avoidance of harmful reactants. Their high selectivity and specificity are especia...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2020-05-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000005/art00009 |
| Summary: | Enzymes are versatile biocatalysts capable of performing selective reactions. The advantages of enzymes in comparison to classical chemistry including chemical catalysts are the generally milder process conditions and avoidance of harmful reactants. Their high selectivity and specificity are especially beneficial for the enzymatic synthesis of new products with potential applications in drug research. Therefore, in the past decades, the utilization of isolated enzymes or whole-cell biocatalysts has spread through a growing number of biotechnological industries. The applications comprise the production of chiral building blocks for the pharmaceutical and fine chemical industry, the enzymatic synthesis of drug metabolites for testing of toxicity, function, biological activity, degradation and the production of biocatalytically modified natural products, which all play a role in drug discovery. Especially Oreste Ghisalba's contributions, which paved the way for the industrial use of enzymes, will be considered in this review. |
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| ISSN: | 0009-4293 2673-2424 |