Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia
Stroke is the leading neurological cause of death and disability all over the world, with few effective drugs. Nerve growth factor (NGF) is well known for its multifaceted neuroprotective functions post-ischemia. However, the lack of an efficient approach to systemically deliver bioactive NGF into i...
Main Authors: | Jialei Yang, Shipo Wu, Lihua Hou, Danni Zhu, Shimin Yin, Guodong Yang, Yongjun Wang |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-09-01
|
Series: | Molecular Therapy: Nucleic Acids |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253120301748 |
Similar Items
-
Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia
by: Jialei Yang, et al.
Published: (2017-06-01) -
Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice
by: Huixin Zhang, et al.
Published: (2019-02-01) -
Surface-modified engineered exosomes attenuated cerebral ischemia/reperfusion injury by targeting the delivery of quercetin towards impaired neurons
by: Lin Guo, et al.
Published: (2021-05-01) -
Biomimetic nerve guidance conduit containing engineered exosomes of adipose-derived stem cells promotes peripheral nerve regeneration
by: Zheng Yang, et al.
Published: (2021-08-01) -
Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope
by: Cynthia Aslan, et al.
Published: (2021-03-01)