Yes-Associated Protein 1 Plays Major Roles in Pancreatic Stellate Cell Activation and Fibroinflammatory Responses

Yes-Associated Protein 1 Plays Major Roles in Pancreatic Stellate Cell Activation and Fibroinflammatory Responses

Background: Yes-associated protein 1 (YAP), a transcriptional co-activator and major effector of the Hippo pathway, regulates cell differentiation and morphology in many cell types and supports aberrant tumor growth. Recent studies showed that YAP is expressed in pancreas tissues in pancreatic ducta...

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Bibliographic Details
Main Authors: Cheng Hu, Jiayue Yang, Hsin-Yuan Su, Richard T. Waldron, Mengmeng Zhi, Ling Li, Qing Xia, Stephen J. Pandol, Aurelia Lugea
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Physiology
Subjects:
pancreatic stellate cells
pancreatitis
pancreatic cancer
yes-associated protein 1
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01467/full

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