Biocatalysis with Laccases: An Updated Overview
Laccases are multicopper oxidases, which have been widely investigated in recent decades thanks to their ability to oxidize organic substrates to the corresponding radicals while producing water at the expense of molecular oxygen. Besides their successful (bio)technological applications, for example...
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doaj-0b67ee7215f14b0998dcd3025aaab3ce2020-12-29T00:03:27ZengMDPI AGCatalysts2073-43442021-12-0111262610.3390/catal11010026Biocatalysis with Laccases: An Updated OverviewIvan Bassanini0Erica Elisa Ferrandi1Sergio Riva2Daniela Monti3Istituto di Scienze e Tecnologie Chimiche “Giulio Natta” (SCITEC), CNR, Via Mario Bianco 9, 20131 Milano, ItalyIstituto di Scienze e Tecnologie Chimiche “Giulio Natta” (SCITEC), CNR, Via Mario Bianco 9, 20131 Milano, ItalyIstituto di Scienze e Tecnologie Chimiche “Giulio Natta” (SCITEC), CNR, Via Mario Bianco 9, 20131 Milano, ItalyIstituto di Scienze e Tecnologie Chimiche “Giulio Natta” (SCITEC), CNR, Via Mario Bianco 9, 20131 Milano, ItalyLaccases are multicopper oxidases, which have been widely investigated in recent decades thanks to their ability to oxidize organic substrates to the corresponding radicals while producing water at the expense of molecular oxygen. Besides their successful (bio)technological applications, for example, in textile, petrochemical, and detoxifications/bioremediations industrial processes, their synthetic potentialities for the mild and green preparation or selective modification of fine chemicals are of outstanding value in biocatalyzed organic synthesis. Accordingly, this review is focused on reporting and rationalizing some of the most recent and interesting synthetic exploitations of laccases. Applications of the so-called laccase-mediator system (LMS) for alcohol oxidation are discussed with a focus on carbohydrate chemistry and natural products modification as well as on bio- and chemo-integrated processes. The laccase-catalyzed Csp<sup>2</sup>-H bonds activation via monoelectronic oxidation is also discussed by reporting examples of enzymatic C-C and C-O radical homo- and hetero-couplings, as well as of aromatic nucleophilic substitutions of hydroquinones or quinoids. Finally, the laccase-initiated domino/cascade synthesis of valuable aromatic (hetero)cycles, elegant strategies widely documented in the literature across more than three decades, is also presented.https://www.mdpi.com/2073-4344/11/1/26laccasebiocatalysisoxidationstereoselectivitylaccase-mediator systemsCsp<sup>2</sup>-H bonds activation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ivan Bassanini Erica Elisa Ferrandi Sergio Riva Daniela Monti |
spellingShingle |
Ivan Bassanini Erica Elisa Ferrandi Sergio Riva Daniela Monti Biocatalysis with Laccases: An Updated Overview Catalysts laccase biocatalysis oxidation stereoselectivity laccase-mediator systems Csp<sup>2</sup>-H bonds activation |
author_facet |
Ivan Bassanini Erica Elisa Ferrandi Sergio Riva Daniela Monti |
author_sort |
Ivan Bassanini |
title |
Biocatalysis with Laccases: An Updated Overview |
title_short |
Biocatalysis with Laccases: An Updated Overview |
title_full |
Biocatalysis with Laccases: An Updated Overview |
title_fullStr |
Biocatalysis with Laccases: An Updated Overview |
title_full_unstemmed |
Biocatalysis with Laccases: An Updated Overview |
title_sort |
biocatalysis with laccases: an updated overview |
publisher |
MDPI AG |
series |
Catalysts |
issn |
2073-4344 |
publishDate |
2021-12-01 |
description |
Laccases are multicopper oxidases, which have been widely investigated in recent decades thanks to their ability to oxidize organic substrates to the corresponding radicals while producing water at the expense of molecular oxygen. Besides their successful (bio)technological applications, for example, in textile, petrochemical, and detoxifications/bioremediations industrial processes, their synthetic potentialities for the mild and green preparation or selective modification of fine chemicals are of outstanding value in biocatalyzed organic synthesis. Accordingly, this review is focused on reporting and rationalizing some of the most recent and interesting synthetic exploitations of laccases. Applications of the so-called laccase-mediator system (LMS) for alcohol oxidation are discussed with a focus on carbohydrate chemistry and natural products modification as well as on bio- and chemo-integrated processes. The laccase-catalyzed Csp<sup>2</sup>-H bonds activation via monoelectronic oxidation is also discussed by reporting examples of enzymatic C-C and C-O radical homo- and hetero-couplings, as well as of aromatic nucleophilic substitutions of hydroquinones or quinoids. Finally, the laccase-initiated domino/cascade synthesis of valuable aromatic (hetero)cycles, elegant strategies widely documented in the literature across more than three decades, is also presented. |
topic |
laccase biocatalysis oxidation stereoselectivity laccase-mediator systems Csp<sup>2</sup>-H bonds activation |
url |
https://www.mdpi.com/2073-4344/11/1/26 |
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