Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism
Granular cell tumours (GCT) are rare, slow-growing, benign neoplasms that are usually located in the head and neck. They are more frequent in the female gender and typically have an asymptomatic clinical course, being diagnosed only at autopsy. Symptomatic GCT of the neurohypophysis are exceedingly...
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Bioscientifica
2018-04-01
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Series: | Endocrinology, Diabetes & Metabolism Case Reports |
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doaj-0b6ec1cd55f341ba9c323c17d3c99bb12020-11-25T00:33:02ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732052-05732018-04-01111510.1530/EDM-17-0178Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarismCarlos Tavares Bello0Patricia Cipriano1Vanessa Henriques2João Sequeira Duarte3Conceição Canas Marques4Endocrinology Department, Hospital de Egas Moniz, Lisbon, Portugal, Internal Medicine Department, HPP Cascais, Cascais, Portugal, Pathology Department, Endocrinology Department, and Neurosurgery Department, Hospital de Egas Moniz, Lisbon, PortugalEndocrinology Department, Hospital de Egas Moniz, Lisbon, Portugal, Internal Medicine Department, HPP Cascais, Cascais, Portugal, Pathology Department, Endocrinology Department, and Neurosurgery Department, Hospital de Egas Moniz, Lisbon, PortugalEndocrinology Department, Hospital de Egas Moniz, Lisbon, Portugal, Internal Medicine Department, HPP Cascais, Cascais, Portugal, Pathology Department, Endocrinology Department, and Neurosurgery Department, Hospital de Egas Moniz, Lisbon, PortugalEndocrinology Department, Hospital de Egas Moniz, Lisbon, Portugal, Internal Medicine Department, HPP Cascais, Cascais, Portugal, Pathology Department, Endocrinology Department, and Neurosurgery Department, Hospital de Egas Moniz, Lisbon, PortugalEndocrinology Department, Hospital de Egas Moniz, Lisbon, Portugal, Internal Medicine Department, HPP Cascais, Cascais, Portugal, Pathology Department, Endocrinology Department, and Neurosurgery Department, Hospital de Egas Moniz, Lisbon, PortugalGranular cell tumours (GCT) are rare, slow-growing, benign neoplasms that are usually located in the head and neck. They are more frequent in the female gender and typically have an asymptomatic clinical course, being diagnosed only at autopsy. Symptomatic GCT of the neurohypophysis are exceedingly rare, being less than 70 cases described so far. The authors report on a case of a 28-year-old male that presented to the Endocrinology clinic with clinical and biochemical evidence of hypogonadism. He also reported minor headaches without any major visual symptoms. Further laboratory tests confirmed hypopituitarism (hypogonadotrophic hypogonadism, central hypothyroidism and hypocortisolism) and central nervous system imaging revealed a pituitary macroadenoma. The patient underwent transcranial pituitary adenoma resection and the pathology report described a GCT of the neurohypophysis with low mitotic index. The reported case is noteworthy for the rarity of the clinicopathological entity.https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0178 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carlos Tavares Bello Patricia Cipriano Vanessa Henriques João Sequeira Duarte Conceição Canas Marques |
spellingShingle |
Carlos Tavares Bello Patricia Cipriano Vanessa Henriques João Sequeira Duarte Conceição Canas Marques Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism Endocrinology, Diabetes & Metabolism Case Reports |
author_facet |
Carlos Tavares Bello Patricia Cipriano Vanessa Henriques João Sequeira Duarte Conceição Canas Marques |
author_sort |
Carlos Tavares Bello |
title |
Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism |
title_short |
Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism |
title_full |
Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism |
title_fullStr |
Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism |
title_full_unstemmed |
Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism |
title_sort |
granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism |
publisher |
Bioscientifica |
series |
Endocrinology, Diabetes & Metabolism Case Reports |
issn |
2052-0573 2052-0573 |
publishDate |
2018-04-01 |
description |
Granular cell tumours (GCT) are rare, slow-growing, benign neoplasms that are usually located in the head and neck. They are more frequent in the female gender and typically have an asymptomatic clinical course, being diagnosed only at autopsy. Symptomatic GCT of the neurohypophysis are exceedingly rare, being less than 70 cases described so far. The authors report on a case of a 28-year-old male that presented to the Endocrinology clinic with clinical and biochemical evidence of hypogonadism. He also reported minor headaches without any major visual symptoms. Further laboratory tests confirmed hypopituitarism (hypogonadotrophic hypogonadism, central hypothyroidism and hypocortisolism) and central nervous system imaging revealed a pituitary macroadenoma. The patient underwent transcranial pituitary adenoma resection and the pathology report described a GCT of the neurohypophysis with low mitotic index. The reported case is noteworthy for the rarity of the clinicopathological entity. |
url |
https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0178 |
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