Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives

Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives

Compounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. Alum (KAl(SO4)2∙12H2O) is an inexpensive, reusable and nontoxic catalyst used to synthesize 1H-pyrazole derivatives via the reaction of 3-methyl-1-phenyl-...

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Bibliographic Details
Main Authors: Mohammad Ali Zolfigol, Ardeshir Khazaei, Fatemeh Karimitabar, Masoud Hamidi
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Applied Sciences
Subjects:
Alum
bispyrazole derivatives
3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
Carbonyl compound
Solvent-free conditions
Online Access:http://www.mdpi.com/2076-3417/6/1/27
Description
Summary:Compounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. Alum (KAl(SO4)2∙12H2O) is an inexpensive, reusable and nontoxic catalyst used to synthesize 1H-pyrazole derivatives via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one and carbonyl compound under solvent-free conditions at 60 °C. The proposed method has been used for the preparation of 1H-pyrazole derivatives to yield green products for cleaning-in-place and to avoid toxic catalysts and hazardous solvents in accordance with the philosophy of sustainable chemistry.
ISSN:2076-3417

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