Innovations, challenges, and minimal information for standardization of humanized mice
Abstract Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo context for understanding of human‐s...
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doaj-0b7a5df243a34bd59c1903d19ca295932021-08-02T18:51:20ZengWileyEMBO Molecular Medicine1757-46761757-46842020-07-01127n/an/a10.15252/emmm.201708662Innovations, challenges, and minimal information for standardization of humanized miceRenata Stripecke0Christian Münz1Jan Jacob Schuringa2Karl‐Dimiter Bissig3Brian Soper4Terrence Meeham5Li‐Chin Yao6James P Di Santo7Michael Brehm8Estefania Rodriguez9Anja Kathrin Wege10Dominique Bonnet11Silvia Guionaud12Kristina E Howard13Scott Kitchen14Florian Klein15Kourosh Saeb‐Parsy16Johannes Sam17Amar Deep Sharma18Andreas Trumpp19Livio Trusolino20Carol Bult21Leonard Shultz22Regenerative Immune Therapies Applied Hannover Medical School Hannover GermanyViral Immunobiology Institute of Experimental Immunology University of Zurich Zurich SwitzerlandDepartment of Hematology University Medical Center Groningen University of Groningen Groningen The NetherlandsDepartment of Pediatrics Duke University Medical Center Durham NC USAThe Jackson Laboratory Bar Harbor ME USAKymab Biotechnology Cambridge UKThe Jackson Laboratory Sacramento CA USAInstitut Pasteur INSERM U1223 ParisFranceUniversity of Massachusetts Medical School Worcester MA USAVirology Dept. Bernhard Nocht Institute for Tropical Medicine Hamburg GermanyDepartment of Gynecology and Obstetrics University Cancer Center Regensburg Regensburg GermanyThe Francis Crick Institute London UKGuionaud Nonclinical Consulting Canterbury UKU.S. Food & Drug Administration Silver Spring MD USAUniversity of California, Los Angeles Los Angeles CA USAUniversity of Cologne Cologne GermanyUniversity of Cambridge Cambridge UKRoche Innovation Center Zurich Zurich SwitzerlandRegenerative Immune Therapies Applied Hannover Medical School Hannover GermanyDivision of Stem Cells and Cancer German Cancer Research Center (DKFZ) Heidelberg GermanyDepartment of Oncology University of Torino Medical School Turin ItalyThe Jackson Laboratory Bar Harbor ME USAThe Jackson Laboratory Bar Harbor ME USAAbstract Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo context for understanding of human‐specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community‐driven resource called “Minimal Information for Standardization of Humanized Mice” (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. Within MISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice.https://doi.org/10.15252/emmm.201708662humanized miceinfectionsPDXimmuno‐oncologyregenerative medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Renata Stripecke Christian Münz Jan Jacob Schuringa Karl‐Dimiter Bissig Brian Soper Terrence Meeham Li‐Chin Yao James P Di Santo Michael Brehm Estefania Rodriguez Anja Kathrin Wege Dominique Bonnet Silvia Guionaud Kristina E Howard Scott Kitchen Florian Klein Kourosh Saeb‐Parsy Johannes Sam Amar Deep Sharma Andreas Trumpp Livio Trusolino Carol Bult Leonard Shultz |
spellingShingle |
Renata Stripecke Christian Münz Jan Jacob Schuringa Karl‐Dimiter Bissig Brian Soper Terrence Meeham Li‐Chin Yao James P Di Santo Michael Brehm Estefania Rodriguez Anja Kathrin Wege Dominique Bonnet Silvia Guionaud Kristina E Howard Scott Kitchen Florian Klein Kourosh Saeb‐Parsy Johannes Sam Amar Deep Sharma Andreas Trumpp Livio Trusolino Carol Bult Leonard Shultz Innovations, challenges, and minimal information for standardization of humanized mice EMBO Molecular Medicine humanized mice infections PDX immuno‐oncology regenerative medicine |
author_facet |
Renata Stripecke Christian Münz Jan Jacob Schuringa Karl‐Dimiter Bissig Brian Soper Terrence Meeham Li‐Chin Yao James P Di Santo Michael Brehm Estefania Rodriguez Anja Kathrin Wege Dominique Bonnet Silvia Guionaud Kristina E Howard Scott Kitchen Florian Klein Kourosh Saeb‐Parsy Johannes Sam Amar Deep Sharma Andreas Trumpp Livio Trusolino Carol Bult Leonard Shultz |
author_sort |
Renata Stripecke |
title |
Innovations, challenges, and minimal information for standardization of humanized mice |
title_short |
Innovations, challenges, and minimal information for standardization of humanized mice |
title_full |
Innovations, challenges, and minimal information for standardization of humanized mice |
title_fullStr |
Innovations, challenges, and minimal information for standardization of humanized mice |
title_full_unstemmed |
Innovations, challenges, and minimal information for standardization of humanized mice |
title_sort |
innovations, challenges, and minimal information for standardization of humanized mice |
publisher |
Wiley |
series |
EMBO Molecular Medicine |
issn |
1757-4676 1757-4684 |
publishDate |
2020-07-01 |
description |
Abstract Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo context for understanding of human‐specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community‐driven resource called “Minimal Information for Standardization of Humanized Mice” (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. Within MISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice. |
topic |
humanized mice infections PDX immuno‐oncology regenerative medicine |
url |
https://doi.org/10.15252/emmm.201708662 |
work_keys_str_mv |
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