| Summary: | Objective: Based on the technology and method of network pharmacology, to explore the
active components and specific mechanism of Simiao powder in the treatment of synovitis.
Methods: by using tcmsp database, the potential active components and related target proteins
of Simiao powder were screened. Genecards and digenet database were used to predict the
target of synovitis. UniProt database was used to query the corresponding gene names. The
compound synovitis target network and protein of Simiao powder were constructed by using
Cytoscape and string software In R language, bio conductor data package was used to analyze
the enrichment of go biological function and KEGG pathway, and the effective components
and targets of Simiao powder in the treatment of synovitis were obtained. Results: 64 key
active components of Simiao powder were screened out from tcmsp database, 71 of them
were involved in the interaction of main chemical components of Simiao powder - chemical
components and synovitis treatment target - synovitis. 95 PPI core genes were obtained, and
90 go biological enrichment processes were obtained by go enrichment analysis. The results
of network pharmacology indicate that Simiaosan can regulate 32 signaling pathways in the
treatment of synovitis, including IL-17 signaling pathway, TNF signaling pathway, T cell
receptor signaling pathway and toll like receptor signaling pathway. Conclusion: the treatment
of synovitis with Simiao powder is a complex process of multi-component, multi-target and
multi-channel, which is related to the coordinated regulation of multiple targets and signal
pathways.
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