Potential mechanism of Simiao powder in treatment of synovitis based on network pharmacology

• Main Authors: Jun-Feng Wang, Xue-Feng Guan
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2021-08-01
• Series: Journal of Hainan Medical University
• Subjects: simiao powder; synovitis; network pharmacology; mechanism of action
• Online Access: http://www.hnykdxxb.com/PDF/202116/10.pdf

Objective: Based on the technology and method of network pharmacology, to explore the active components and specific mechanism of Simiao powder in the treatment of synovitis. Methods: by using tcmsp database, the potential active components and related target proteins of Simiao powder were screened. Genecards and digenet database were used to predict the target of synovitis. UniProt database was used to query the corresponding gene names. The compound synovitis target network and protein of Simiao powder were constructed by using Cytoscape and string software In R language, bio conductor data package was used to analyze the enrichment of go biological function and KEGG pathway, and the effective components and targets of Simiao powder in the treatment of synovitis were obtained. Results: 64 key active components of Simiao powder were screened out from tcmsp database, 71 of them were involved in the interaction of main chemical components of Simiao powder - chemical components and synovitis treatment target - synovitis. 95 PPI core genes were obtained, and 90 go biological enrichment processes were obtained by go enrichment analysis. The results of network pharmacology indicate that Simiaosan can regulate 32 signaling pathways in the treatment of synovitis, including IL-17 signaling pathway, TNF signaling pathway, T cell receptor signaling pathway and toll like receptor signaling pathway. Conclusion: the treatment of synovitis with Simiao powder is a complex process of multi-component, multi-target and multi-channel, which is related to the coordinated regulation of multiple targets and signal pathways.