Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent an undesirable outcome of therapy by providing...
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doaj-0b9798c39d2e4f999d0aff471e35555f2020-11-24T23:57:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-05-01810.3389/fonc.2018.00164319340Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer TherapyTareq Saleh0Tareq Saleh1Liliya Tyutynuk-Massey2Liliya Tyutynuk-Massey3Emmanuel K. Cudjoe4Michael O. Idowu5Joseph W. Landry6Joseph W. Landry7David A. Gewirtz8David A. Gewirtz9Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United StatesMassey Cancer Center, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United StatesMassey Cancer Center, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Pathology, Virginia Commonwealth University, Richmond, VA, United StatesMassey Cancer Center, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United StatesMassey Cancer Center, Virginia Commonwealth University, Richmond, VA, United StatesIn addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent an undesirable outcome of therapy by providing a mechanism for tumor dormancy and eventual disease recurrence. The senescence-associated secretory phenotype (SASP) is a hallmark of TIS and may contribute to aberrant effects of cancer therapy. Here, we propose that the SASP may also serve as a major driver of escape from senescence and the re-emergence of proliferating tumor cells, wherein factors secreted from the senescent cells contribute to the restoration of tumor growth in a non-cell autonomous fashion. Accordingly, anti-SASP therapies might serve to mitigate the deleterious outcomes of TIS. In addition to providing an overview of the putative actions of the SASP, we discuss recent efforts to identify and eliminate senescent tumor cells.https://www.frontiersin.org/article/10.3389/fonc.2018.00164/fullsenescencesenescence-associated secretory phenotypechemotherapysenolysisdormancyrecurrence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tareq Saleh Tareq Saleh Liliya Tyutynuk-Massey Liliya Tyutynuk-Massey Emmanuel K. Cudjoe Michael O. Idowu Joseph W. Landry Joseph W. Landry David A. Gewirtz David A. Gewirtz |
spellingShingle |
Tareq Saleh Tareq Saleh Liliya Tyutynuk-Massey Liliya Tyutynuk-Massey Emmanuel K. Cudjoe Michael O. Idowu Joseph W. Landry Joseph W. Landry David A. Gewirtz David A. Gewirtz Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy Frontiers in Oncology senescence senescence-associated secretory phenotype chemotherapy senolysis dormancy recurrence |
author_facet |
Tareq Saleh Tareq Saleh Liliya Tyutynuk-Massey Liliya Tyutynuk-Massey Emmanuel K. Cudjoe Michael O. Idowu Joseph W. Landry Joseph W. Landry David A. Gewirtz David A. Gewirtz |
author_sort |
Tareq Saleh |
title |
Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy |
title_short |
Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy |
title_full |
Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy |
title_fullStr |
Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy |
title_full_unstemmed |
Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy |
title_sort |
non-cell autonomous effects of the senescence-associated secretory phenotype in cancer therapy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2018-05-01 |
description |
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent an undesirable outcome of therapy by providing a mechanism for tumor dormancy and eventual disease recurrence. The senescence-associated secretory phenotype (SASP) is a hallmark of TIS and may contribute to aberrant effects of cancer therapy. Here, we propose that the SASP may also serve as a major driver of escape from senescence and the re-emergence of proliferating tumor cells, wherein factors secreted from the senescent cells contribute to the restoration of tumor growth in a non-cell autonomous fashion. Accordingly, anti-SASP therapies might serve to mitigate the deleterious outcomes of TIS. In addition to providing an overview of the putative actions of the SASP, we discuss recent efforts to identify and eliminate senescent tumor cells. |
topic |
senescence senescence-associated secretory phenotype chemotherapy senolysis dormancy recurrence |
url |
https://www.frontiersin.org/article/10.3389/fonc.2018.00164/full |
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