Quorum Quenching Revisited—From Signal Decays to Signalling Confusion
In a polymicrobial community, while some bacteria are communicating with neighboring cells (quorum sensing), others are interrupting the communication (quorum quenching), thus creating a constant arms race between intercellular communication. In the past decade, numerous quorum quenching enzymes hav...
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doaj-0b99a01f513f47f4a5701f8aa7b660482020-11-25T00:55:22ZengMDPI AGSensors1424-82202012-04-011244661469610.3390/s120404661Quorum Quenching Revisited—From Signal Decays to Signalling ConfusionKok-Gan ChanChong-Lek KohWai-Fong YinChoon-Kook SamKar-Wai HongIn a polymicrobial community, while some bacteria are communicating with neighboring cells (quorum sensing), others are interrupting the communication (quorum quenching), thus creating a constant arms race between intercellular communication. In the past decade, numerous quorum quenching enzymes have been found and initially thought to inactivate the signalling molecules. Though this is widely accepted, the actual roles of these quorum quenching enzymes are now being uncovered. Recent evidence extends the role of quorum quenching to detoxification or metabolism of signalling molecules as food and energy source; this includes “signalling confusion”, a term coined in this paper to refer to the phenomenon of non-destructive modification of signalling molecules. While quorum quenching has been explored as a novel anti-infective therapy targeting, quorum sensing evidence begins to show the development of resistance against quorum quenching.http://www.mdpi.com/1424-8220/12/4/4661/acylaseanti-infectiveanti-biofoulingaquaculturelactonaseN-acylhomoserine lactoneparaoxonaseoxidoreductasequorum sensingquorum quenching resistancesignalling confusion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kok-Gan Chan Chong-Lek Koh Wai-Fong Yin Choon-Kook Sam Kar-Wai Hong |
spellingShingle |
Kok-Gan Chan Chong-Lek Koh Wai-Fong Yin Choon-Kook Sam Kar-Wai Hong Quorum Quenching Revisited—From Signal Decays to Signalling Confusion Sensors acylase anti-infective anti-biofouling aquaculture lactonase N-acylhomoserine lactone paraoxonase oxidoreductase quorum sensing quorum quenching resistance signalling confusion |
author_facet |
Kok-Gan Chan Chong-Lek Koh Wai-Fong Yin Choon-Kook Sam Kar-Wai Hong |
author_sort |
Kok-Gan Chan |
title |
Quorum Quenching Revisited—From Signal Decays to Signalling Confusion |
title_short |
Quorum Quenching Revisited—From Signal Decays to Signalling Confusion |
title_full |
Quorum Quenching Revisited—From Signal Decays to Signalling Confusion |
title_fullStr |
Quorum Quenching Revisited—From Signal Decays to Signalling Confusion |
title_full_unstemmed |
Quorum Quenching Revisited—From Signal Decays to Signalling Confusion |
title_sort |
quorum quenching revisited—from signal decays to signalling confusion |
publisher |
MDPI AG |
series |
Sensors |
issn |
1424-8220 |
publishDate |
2012-04-01 |
description |
In a polymicrobial community, while some bacteria are communicating with neighboring cells (quorum sensing), others are interrupting the communication (quorum quenching), thus creating a constant arms race between intercellular communication. In the past decade, numerous quorum quenching enzymes have been found and initially thought to inactivate the signalling molecules. Though this is widely accepted, the actual roles of these quorum quenching enzymes are now being uncovered. Recent evidence extends the role of quorum quenching to detoxification or metabolism of signalling molecules as food and energy source; this includes “signalling confusion”, a term coined in this paper to refer to the phenomenon of non-destructive modification of signalling molecules. While quorum quenching has been explored as a novel anti-infective therapy targeting, quorum sensing evidence begins to show the development of resistance against quorum quenching. |
topic |
acylase anti-infective anti-biofouling aquaculture lactonase N-acylhomoserine lactone paraoxonase oxidoreductase quorum sensing quorum quenching resistance signalling confusion |
url |
http://www.mdpi.com/1424-8220/12/4/4661/ |
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