APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome

APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome

Intellectual disability in Down syndrome (DS) appears to be related to severe neurogenesis impairment during brain development. The molecular mechanisms underlying this defect are still largely unknown. Accumulating evidence has highlighted the importance of GSK3β signaling for neuronal precursor pr...

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Bibliographic Details
Main Authors: Stefania Trazzi, Claudia Fuchs, Marianna De Franceschi, Valentina Maria Mitrugno, Renata Bartesaghi, Elisabetta Ciani
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Neurobiology of Disease
Subjects:
Down syndrome
Neurogenesis impairment
GSK3β
APP
AICD
5-HT1A receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000576

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http://www.sciencedirect.com/science/article/pii/S0969996114000576

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