Itch in Allergic Contact Dermatitis

Contact dermatitis is a continuous growing environmental and occupational health problem. It results in high costs for health care systems and the economy due to productivity loss. Moreover, it has a huge impact on the quality of life of patients. The immune response to contact allergy is very compl...

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Bibliographic Details
Main Author:	Julien Lambert
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-10-01
Series:	Frontiers in Allergy
Subjects:	itch pruritus contact dermatitis contact allergy mast cells
Online Access:	https://www.frontiersin.org/articles/10.3389/falgy.2021.702488/full

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spelling	doaj-0b9e70392ca74540b850ec40ca4020462021-10-04T05:03:11ZengFrontiers Media S.A.Frontiers in Allergy2673-61012021-10-01210.3389/falgy.2021.702488702488Itch in Allergic Contact DermatitisJulien Lambert0Julien Lambert1Antwerp University Hospital, Antwerp, BelgiumUniversity of Antwerp, Antwerp, BelgiumContact dermatitis is a continuous growing environmental and occupational health problem. It results in high costs for health care systems and the economy due to productivity loss. Moreover, it has a huge impact on the quality of life of patients. The immune response to contact allergy is very complex and not totally elucidated. Recently unique pathways preferentially activated by different allergens were identified. As for a lot of chronic itch disorders, antihistamines are ineffective for allergic contact dermatitis, suggesting a non-histaminergic itch. The precise mechanisms that underlie the development of itch in ACD remain poorly defined. This short review addresses the most recent insights in pruritus in ACD, opening perspectives for future therapies.https://www.frontiersin.org/articles/10.3389/falgy.2021.702488/fullitchprurituscontact dermatitiscontact allergymast cells
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Julien Lambert Julien Lambert
spellingShingle	Julien Lambert Julien Lambert Itch in Allergic Contact Dermatitis Frontiers in Allergy itch pruritus contact dermatitis contact allergy mast cells
author_facet	Julien Lambert Julien Lambert
author_sort	Julien Lambert
title	Itch in Allergic Contact Dermatitis
title_short	Itch in Allergic Contact Dermatitis
title_full	Itch in Allergic Contact Dermatitis
title_fullStr	Itch in Allergic Contact Dermatitis
title_full_unstemmed	Itch in Allergic Contact Dermatitis
title_sort	itch in allergic contact dermatitis
publisher	Frontiers Media S.A.
series	Frontiers in Allergy
issn	2673-6101
publishDate	2021-10-01
description	Contact dermatitis is a continuous growing environmental and occupational health problem. It results in high costs for health care systems and the economy due to productivity loss. Moreover, it has a huge impact on the quality of life of patients. The immune response to contact allergy is very complex and not totally elucidated. Recently unique pathways preferentially activated by different allergens were identified. As for a lot of chronic itch disorders, antihistamines are ineffective for allergic contact dermatitis, suggesting a non-histaminergic itch. The precise mechanisms that underlie the development of itch in ACD remain poorly defined. This short review addresses the most recent insights in pruritus in ACD, opening perspectives for future therapies.
topic	itch pruritus contact dermatitis contact allergy mast cells
url	https://www.frontiersin.org/articles/10.3389/falgy.2021.702488/full
work_keys_str_mv	AT julienlambert itchinallergiccontactdermatitis AT julienlambert itchinallergiccontactdermatitis
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Itch in Allergic Contact Dermatitis

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