Epigenetic DNA changes and stem cells therapy

• Main Authors: Stupar Milanko, Vidović Vitomir, Baltić Vladimir, Štrbac Ljuba, Lukač Dragomir
• Format: Article
• Language: English
• Published: Institute of Oncology, Sremska Kamenica, Serbia 2013-01-01
• Series: Archive of Oncology
• Subjects: DNA; RNA; Epigenesis; Genetic; Environment; Neoplasms; Antineoplastic Agents; Stem Cells
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-7310/2013/0354-73101301024S.pdf

We are starting to understand the fundamental biological processes which underlie the DNA physical properties. Of particular importance is the field of epigenetics, which literally means 'outside conventional genetics', now used to describe the study of stable alterations in gene expression potential that arise during development and cell proliferation. Epigenetic changes are modifications of DNA, which occur without any alteration in the DNA sequence. Modern directions in the field of epigenetic research aimed to decipher the epigenetic signals that give stem cells their unique ability to self-renew and differentiate into different types. Stem cell-based regenerative medicine holds great promise for repair of diseased tissue. If epigenetic process are reversible, than there is the ability to cure cancer through stem cell therapy.