Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort
Objective: Secretory phospholipase A2 (sPLA2) enzyme activity is a potential inflammatory biomarker for cardiovascular disease. We examined the tracking, or persistence, of sPLA2 enzyme activity levels from childhood to adulthood, and identify potentially modifiable factors affecting tracking. Metho...
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Elsevier
2019-03-01
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Series: | Jornal de Pediatria |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0021755717311683 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Olivia Chung Markus Juonala Ziad Mallat Nina Hutri-Kähönen Jorma S.A. Viikari Olli T. Raitakari Costan G. Magnussen |
spellingShingle |
Olivia Chung Markus Juonala Ziad Mallat Nina Hutri-Kähönen Jorma S.A. Viikari Olli T. Raitakari Costan G. Magnussen Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort Jornal de Pediatria |
author_facet |
Olivia Chung Markus Juonala Ziad Mallat Nina Hutri-Kähönen Jorma S.A. Viikari Olli T. Raitakari Costan G. Magnussen |
author_sort |
Olivia Chung |
title |
Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort |
title_short |
Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort |
title_full |
Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort |
title_fullStr |
Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort |
title_full_unstemmed |
Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort |
title_sort |
tracking of secretory phospholipase a2 enzyme activity levels from childhood to adulthood: a 21-year cohort |
publisher |
Elsevier |
series |
Jornal de Pediatria |
issn |
0021-7557 |
publishDate |
2019-03-01 |
description |
Objective: Secretory phospholipase A2 (sPLA2) enzyme activity is a potential inflammatory biomarker for cardiovascular disease. We examined the tracking, or persistence, of sPLA2 enzyme activity levels from childhood to adulthood, and identify potentially modifiable factors affecting tracking. Method: Prospective cohort of 1735 children (45% females) who had serum sPLA2 enzyme activity levels and other cardiovascular disease risk factors measured in 1980 that were followed-up in 2001. Results: sPLA2 activity tracked from childhood to adulthood for males (r = 0.39) and females (r = 0.45). Those who decreased body mass index relative to their peers were more likely to resolve elevated childhood sPLA2 levels than have persistent elevated sPLA2 levels in childhood and adulthood. Those who consumed less fruit, and gained more body mass index relative to their peers, began smoking or were a persistent smoker between childhood and adulthood were more likely to develop incident elevated sPLA2 levels than those with persistent not elevated sPLA2 levels. Conclusions: Childhood sPLA2 enzyme activity levels associate with adult sPLA2 levels 21 years later. Healthful changes in modifiable risk factors that occur between childhood and adulthood might prevent children from developing elevated sPLA2 levels in adulthood. Resumo: Objetivo: A atividade da enzima fosfolipase A2 secretória (sPLA2) é um possível biomarcador inflamatório de doença cardiovascular. Examinamos o monitoramento, ou a persistência, dos níveis de atividade da enzima sPLA2 da infância à vida adulta e identificamos fatores possivelmente modificáveis que afetam o monitoramento. Método: Coorte prospectiva de 1.735 crianças (45% do sexo feminino) cujos níveis de atividade da enzima sPLA2 no soro e outros fatores de risco para doença cardiovascular foram medidos em 1980 e acompanhados até 2011. Resultados: Atividade da enzima sPLA2 monitorada da infância à vida adulta para indivíduos do sexo masculino (r = 0,39) e sexo feminino (r = 0,45). Aqueles que diminuíram seus índices de massa corporal com relação a seus pares foram mais propensos à redução dos níveis elevados de sPLA2 na infância do que a manter níveis persistentemente elevados de sPLA2 na infância e vida adulta. Aqueles que consumiram menos frutas e ganharam mais índice de massa corporal com relação a seus pares, que começaram a fumar ou foram fumantes persistentes entre a infância e vida adulta foram mais propensos a desenvolver níveis de sPLA2 elevados do que aqueles com níveis de sPLA2 não elevados persistentes. Conclusões: Os níveis de atividade da enzima sPLA2 na infância estão associados aos níveis de sPLA2 na vida adulta, 21 anos mais tarde. As mudanças saudáveis nos fatores de risco modificáveis que ocorrem entre a infância e a vida adulta podem evitar que as crianças desenvolvam níveis elevados de sPLA2 na vida adulta. Keywords: Atherosclerosis, Cohort study, Inflammation, Prevention, Palavras-chave: Aterosclerose, Estudo de coorte, Inflamação, Prevenção |
url |
http://www.sciencedirect.com/science/article/pii/S0021755717311683 |
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AT oliviachung trackingofsecretoryphospholipasea2enzymeactivitylevelsfromchildhoodtoadulthooda21yearcohort AT markusjuonala trackingofsecretoryphospholipasea2enzymeactivitylevelsfromchildhoodtoadulthooda21yearcohort AT ziadmallat trackingofsecretoryphospholipasea2enzymeactivitylevelsfromchildhoodtoadulthooda21yearcohort AT ninahutrikahonen trackingofsecretoryphospholipasea2enzymeactivitylevelsfromchildhoodtoadulthooda21yearcohort AT jormasaviikari trackingofsecretoryphospholipasea2enzymeactivitylevelsfromchildhoodtoadulthooda21yearcohort AT ollitraitakari trackingofsecretoryphospholipasea2enzymeactivitylevelsfromchildhoodtoadulthooda21yearcohort AT costangmagnussen trackingofsecretoryphospholipasea2enzymeactivitylevelsfromchildhoodtoadulthooda21yearcohort |
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doaj-0ba3eb7d5b73435eb7d0ad5f5ba8fe1e2020-11-25T02:26:01ZengElsevierJornal de Pediatria0021-75572019-03-01952247254Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohortOlivia Chung0Markus Juonala1Ziad Mallat2Nina Hutri-Kähönen3Jorma S.A. Viikari4Olli T. Raitakari5Costan G. Magnussen6University of Tasmania, Menzies Institute for Medical Research, Hobart, AustraliaUniversity of Turku, Department of Medicine, Turku, Finland; Turku University Hospital, Division of Medicine, Turku, FinlandUniversity of Cambridge, Department of Medicine, Cambridge, United Kingdom; Inserm U970, Cardiovascular Research Center, Paris, France; Université Paris-Descartes, Paris, FranceUniversity of Tampere, Department of Pediatrics, Tampere, Finland; Tampere University Hospital, Tampere, FinlandUniversity of Turku, Department of Medicine, Turku, Finland; Turku University Hospital, Division of Medicine, Turku, FinlandUniversity of Turku, Research Centre of Applied and Preventive Cardiovascular Medicine, Turku, Finland; University of Turku, Department of Clinical Physiology, Turku, FinlandUniversity of Tasmania, Menzies Institute for Medical Research, Hobart, Australia; University of Turku, Research Centre of Applied and Preventive Cardiovascular Medicine, Turku, Finland; Corresponding author.Objective: Secretory phospholipase A2 (sPLA2) enzyme activity is a potential inflammatory biomarker for cardiovascular disease. We examined the tracking, or persistence, of sPLA2 enzyme activity levels from childhood to adulthood, and identify potentially modifiable factors affecting tracking. Method: Prospective cohort of 1735 children (45% females) who had serum sPLA2 enzyme activity levels and other cardiovascular disease risk factors measured in 1980 that were followed-up in 2001. Results: sPLA2 activity tracked from childhood to adulthood for males (r = 0.39) and females (r = 0.45). Those who decreased body mass index relative to their peers were more likely to resolve elevated childhood sPLA2 levels than have persistent elevated sPLA2 levels in childhood and adulthood. Those who consumed less fruit, and gained more body mass index relative to their peers, began smoking or were a persistent smoker between childhood and adulthood were more likely to develop incident elevated sPLA2 levels than those with persistent not elevated sPLA2 levels. Conclusions: Childhood sPLA2 enzyme activity levels associate with adult sPLA2 levels 21 years later. Healthful changes in modifiable risk factors that occur between childhood and adulthood might prevent children from developing elevated sPLA2 levels in adulthood. Resumo: Objetivo: A atividade da enzima fosfolipase A2 secretória (sPLA2) é um possível biomarcador inflamatório de doença cardiovascular. Examinamos o monitoramento, ou a persistência, dos níveis de atividade da enzima sPLA2 da infância à vida adulta e identificamos fatores possivelmente modificáveis que afetam o monitoramento. Método: Coorte prospectiva de 1.735 crianças (45% do sexo feminino) cujos níveis de atividade da enzima sPLA2 no soro e outros fatores de risco para doença cardiovascular foram medidos em 1980 e acompanhados até 2011. Resultados: Atividade da enzima sPLA2 monitorada da infância à vida adulta para indivíduos do sexo masculino (r = 0,39) e sexo feminino (r = 0,45). Aqueles que diminuíram seus índices de massa corporal com relação a seus pares foram mais propensos à redução dos níveis elevados de sPLA2 na infância do que a manter níveis persistentemente elevados de sPLA2 na infância e vida adulta. Aqueles que consumiram menos frutas e ganharam mais índice de massa corporal com relação a seus pares, que começaram a fumar ou foram fumantes persistentes entre a infância e vida adulta foram mais propensos a desenvolver níveis de sPLA2 elevados do que aqueles com níveis de sPLA2 não elevados persistentes. Conclusões: Os níveis de atividade da enzima sPLA2 na infância estão associados aos níveis de sPLA2 na vida adulta, 21 anos mais tarde. As mudanças saudáveis nos fatores de risco modificáveis que ocorrem entre a infância e a vida adulta podem evitar que as crianças desenvolvam níveis elevados de sPLA2 na vida adulta. Keywords: Atherosclerosis, Cohort study, Inflammation, Prevention, Palavras-chave: Aterosclerose, Estudo de coorte, Inflamação, Prevençãohttp://www.sciencedirect.com/science/article/pii/S0021755717311683 |