Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis

• Main Authors: Divakar Sharma, Yogesh K. Dhuriya, Nirmala Deo, Deepa Bisht
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2017-12-01
• Series: Frontiers in Microbiology
• Subjects: drug resistance tuberculosis; repurposing; revival of drugs; synergistic effect; proteomics and bioinformatics
• Online Access: http://journal.frontiersin.org/article/10.3389/fmicb.2017.02452/full
• ISSN: 1664-302X

Emergence of drug resistant tuberculosis like multi drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and totally drug resistant tuberculosis (TDR-TB) has created a new challenge to fight against these bad bugs of Mycobacterium tuberculosis. Repurposing and revival of the drugs are the new trends/options to combat these worsen situations of tuberculosis in the antibiotics resistance era or in the situation of global emergency. Bactericidal and synergistic effect of repurposed/revived drugs along with the latest drugs bedaquiline and delamanid used in the treatment of MDR-TB, XDR-TB, and TDR-TB might be the choice for future promising combinatorial chemotherapy against these bad bugs.